NIH RePORTER
Cure8 research brief
Why This Matters
Researchers are investigating fungal contributions to IBD-related gut inflammation; understanding fungal persistence mechanisms could eventually inform therapies or diagnostics for dysbiosis-associated worsening of disease.
For people with IBD, fungal overgrowth (Candida) during inflammation may influence disease severity, so this work aims to clarify those mechanisms in preclinical models.
Who Should Pay Attention
Researchers studying host–microbe interactions, mucosal immunology, fungal pathogenesis, and microbiome-focused IBD research; clinicians interested in microbiome-driven contributors to IBD; basic science trainees.
Study Snapshot
Story typeClinical Reference
Evidence typeFunded research project
Study statusFunded
Source depthResearch project record
What To Know
NIH Reporter describes a predoctoral research project investigating fungal contributions to gut inflammation in IBD using mouse models and molecular tools. The project centers on Candida albicans biology during DSS colitis, with Bcr1 identified as a candidate regulator of biofilm-associated growth and colonization fitness.
Planned methods include RNA sequencing of fungi during inflammation, microscopy to assess biofilm-like aggregates, and testing single and double gene-deletion mutants (BCR1, SAP genes) to probe mechanisms. Results are not reported in this abstract; this is a funded study describing aims and approaches.
The project is training-focused (F31) and emphasizes mentorship and skill development alongside the research, preparing the trainee for an independent research career.
Keep In Mind
This is a funded predoctoral research project (F31) with aims and planned experiments; it is not a peer-reviewed study report and contains no clinical results. The work uses a DSS-induced colitis mouse model and molecular microbiology approaches—findings in mice may not directly translate to humans.
Source Details
Review the original publication for the complete reporting, methods, and context.
Funded research project
Evidence type derived from source or registry metadata.
PublicationNIH RePORTER
AuthorsEmma N Trujillo
InstitutionUNIVERSITY OF COLORADO DENVER
Study typeFunded Research Project
Indexed viaNIH RePORTER
Source typeFunded research record
PublishedSep 1, 2026, 12:00 AM
Content availableResearch project record
Funding disclosed by the source: National Institute of Allergy and Infectious Diseases - F31AI197329 - $38,798
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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