NIH RePORTER
Cure8 regulatory brief
Why This Matters
This project aims to map microbe-specific T cells in Crohn's disease using single-cell RNA and TCR sequencing. Findings could reveal antigen-specific mechanisms driving IBD and help lay groundwork for targeted diagnostics or therapies beyond broad immunosuppression.
Who Should Pay Attention
Researchers, clinicians focused on IBD immunology and biologics, and patients interested in the microbiome and antigen-directed therapies
Study Snapshot
Story typeRegulatory
Evidence typeFunded research project
Study statusFunded
Source depthResearch project record
What To Know
The team will longitudinally profile T cell repertoires and phenotypes in people with Crohn's disease who do and do not respond to anti-IL-23 therapy, plus healthy controls and HLA+ microbiome–matched humanized mice. They plan to prioritize TCRs for cloning and screen them to identify microbiome-specific T cells and characterize their phenotypes.
These are translational, preclinical and human profiling studies intended to map which microbes are targeted by antigen-specific T cells and how those cells differ in health versus disease. The work aims to build a path toward antigen-specific diagnostics or therapies but does not report clinical results or new treatments yet.
Keep In Mind
This is a funded research project (NIH Reporter project record). It describes planned laboratory and translational work (single-cell and TCR sequencing, humanized-mouse models) and does not present clinical trial results. Any therapeutic applications are future goals.
Source Details
Review the original publication for the complete reporting, methods, and context.
Funded research project
Evidence type derived from source or registry metadata.
PublicationNIH RePORTER
AuthorsJeremiah James Faith, Dan Littman, Saurabh Mehandru
InstitutionICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Study typeFunded Research Project
Indexed viaNIH RePORTER
Source typeFunded research record
PublishedSep 1, 2026, 12:00 AM
Content availableResearch project record
Funding disclosed by the source: National Institute of Diabetes and Digestive and Kidney Diseases - R01DK146930 - $726,142
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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