NIH RePORTER
Cure8 regulatory brief
Bile acid control of commensal-specific immune responses
Research and clinical trials
Microbiome
Clinical study
Researchers
Clinicians
Inflammatory bowel disease
Crohn's disease
Why This Matters
This project explores how gut microbes and bile acids interact to shape immune cells in the ileum — a process that may affect inflammation in Crohn’s disease and other IBDs. Understanding these mechanisms could point to new ways to promote tolerance in the gut.
Who Should Pay Attention
Researchers studying microbiome–immune interactions, basic scientists working on bile acids or nuclear receptors, and clinicians interested in mechanistic IBD research and future therapeutic strategies.
Study Snapshot
Story typeRegulatory
Evidence typeFunded research project
Study statusFunded
Source depthResearch project record
What To Know
This NIH-funded project record describes laboratory and mouse studies investigating how enterohepatic bile acid (BA) pools shaped by ileal commensal bacteria (segmented filamentous bacteria, SFB) influence development of tolerogenic commensal-specific Th17 cells via nuclear receptors (RORɣt, PPARɣ) and macrophage signaling.
The team plans mechanistic experiments using in vitro and in vivo systems (mouse models, molecular assays such as ATAC-seq) to map BA–NR interactions, define how SFB remodel BA pools, and test how those changes affect mucosal immune responses.
The goal is to lay groundwork for BA-based strategies to restore intestinal immune tolerance in infectious or inflammatory diseases including IBD.
Keep In Mind
This is a funded research project (NIH Reporter entry) describing preclinical mechanistic work in mice and molecular systems; it is not a clinical trial and does not report results in humans. Findings are exploratory and intended to inform future translational work.
Source Details
Review the original publication for the complete reporting, methods, and context.
Funded research project
Evidence type derived from source or registry metadata.
PublicationNIH RePORTER
AuthorsIvaylo Ivanov Ivanov, Mark Scott Sundrud
InstitutionDARTMOUTH-HITCHCOCK CLINIC
Study typeFunded Research Project
Indexed viaNIH RePORTER
Source typeFunded research record
PublishedJul 24, 2026, 12:00 AM
Content availableResearch project record
Funding disclosed by the source: National Institute of Allergy and Infectious Diseases - U01AI201086 - $561,873
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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