Cure8 research brief
Effective nursing-led support during clinical trial participation may improve engagement, adherence, retention, and timely symptom reporting for people with IBD. That could make trials safer, fairer, and more reliable and reduce burdens on participants during transitions into and out of studies.
IBD clinicians and trial teams, clinical research nurses, trial designers, and patients or caregivers considering participation in IBD clinical studies.
The paper synthesizes heterogeneous literature using realist-informed interpretation rather than performing a formal realist review.
It highlights five supportive nursing functions that repeatedly appear important across studies and settings: clear expectation-setting during screening/enrolment; education tailored to health literacy plus teach-back; ongoing mixed-mode contact to maintain relational continuity; extra support during transitions (entry, amendment, exit); and governance measures to ensure safety, equity, and role clarity.
These nursing activities are presented as potential "mechanism-bearing" components that could improve participant trust, self-efficacy, protocol adherence, timely symptom reporting, and retention — all of which matter for trial quality and participant safety.
The review focuses on implementation and contextual factors rather than reporting new trial outcomes.
The article is a narrative review using realist-informed interpretive principles and synthesizes diverse literature; it does not present new trial data or formal quantitative synthesis.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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