BMJ case reports
Cure8 research brief
Ocrelizumab-induced colitis acutely managed with ciclosporin.
Complications
Corticosteroids
Steroids
Case Report
Clinicians
Patients with Perianal Disease
Inflammatory bowel disease
Why This Matters
A rare but serious colitis linked to ocrelizumab is described and managed successfully with ciclosporin in a steroid‑refractory case; this may be relevant to clinicians caring for patients on B‑cell–depleting therapy.
Who Should Pay Attention
Clinicians treating MS patients on ocrelizumab, gastroenterologists, and specialists managing drug‑induced colitis; informed patients on B‑cell–depleting therapy.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
A patient developed steroid‑refractory colitis after ocrelizumab; infective causes and classical IBD were excluded. Ciclosporin was used as a salvage therapy with reported effectiveness, and the team monitored ciclosporin drug levels and neurotoxicity while involving a multidisciplinary team to guide safe titration.
The report is a single case in BMJ Case Reports. It illustrates a management approach rather than proving effectiveness; clinicians should interpret it as a potential option in closely monitored, specialist settings and not as standard first‑line therapy.
Keep In Mind
Single‑patient case report (BMJ Case Reports) presented at abstract depth; findings are hypothesis‑generating and require cautious interpretation. Therapeutic drug monitoring and neurotoxicity surveillance were highlighted as important safety steps.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationBMJ case reports
AuthorsStephanie Dimovski, Maddison Terlato, Jonathan P Segal
InstitutionDepartment of Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia stephanie.dimovski@mh.org.au.
Study typeJournal article, case reports
Indexed viaPubMed
Source typeResearch paper
PublishedJul 22, 2026, 12:00 AM
Content availableJournal abstract
Conflict statement: Competing interests: None declared.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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