Cure8 research brief
People with IBD may face higher-than-expected rates of hypertensive disorders in pregnancy; identifying predictors could help target monitoring and preventive strategies. The study suggests prior HDP and gestational diabetes predict HDP risk, while IBD activity during pregnancy did not appear to increase risk.
Pregnant patients with IBD, gastroenterologists, obstetricians/maternal‑fetal medicine clinicians, and caregivers involved in pregnancy planning
This study reviewed singleton pregnancies in people with IBD delivered at a single academic center from 2019–2023. The primary outcome was development of HDP (gestational hypertension or preeclampsia). Patients with a prior history of hypertensive disorders in pregnancy and those who developed gestational diabetes were more likely to have HDP in this cohort.
Measures of IBD activity, including clinical remission and flares during pregnancy, did not differ between those who did and did not develop HDP. The authors also reported that fetal fraction on cell‑free DNA testing was lower in pregnancies complicated by HDP.
Only 16% of patients received low‑dose aspirin for preeclampsia prophylaxis; the study notes hesitancy to use NSAID/aspirin in pregnancy among people with IBD and calls for further research on risks and benefits.
Single‑center retrospective study of 100 deliveries (2019–2023). Results are limited by sample size and observational design. The article presents an abstract-level summary; further multi-center studies are needed to guide practice, especially regarding low‑dose aspirin use in IBD pregnancies.
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This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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