Cure8 trial brief
This trial could show whether intra-operative ultrasound can be used reliably to choose the proximal resection margin during ileocecal resection for terminal ileal Crohn’s disease—information that might affect surgical practice and study of post-operative recurrence.
Adults with terminal ileal Crohn's disease considering primary ileocolic resection; colorectal surgeons and surgical researchers; IBD clinicians following post-operative recurrence strategies.
This is a small, single-center, randomized Phase II trial at the Cleveland Clinic enrolling adults having primary ileocolic resection for terminal ileal Crohn’s disease.
Participants are randomized to IOUS-guided margin selection (Margin B defined by mural thickness ≤2.5 mm and preserved wall stratification) versus standard macroscopic margin selection (Margin A).
The primary outcome listed is feasibility of performing IOUS and designating Margin B intraoperatively; other collected outcomes include histopathology, operative and safety data, and endoscopic recurrence except in patients who require a stoma. The trial is recruiting and plans to enroll 22 participants.
The study protocol and eligibility criteria are described in the registry entry. Because this is a trial record, these are planned methods and outcomes rather than results; no clinical findings or benefits are reported in the registry entry.
This is a Phase II, single-center randomized trial (Cleveland Clinic) focused on feasibility and methodological outcomes; the registry lists planned enrollment and eligibility but provides no results. Interpret as planned research rather than evidence of benefit.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
Surgical technique after ileocolic resection may influence how likely Crohn’s disease is to come back near the anastomosis.
Surgery is common in Crohn’s disease and different types of resections carry different short-term risks.
Surgery remains an important treatment option for Crohn’s disease and may be considered earlier for some patients. Decisions about timing, technique, and perioperative care can affect long-term outcomes and recurrence...
