Cure8 research brief
Postoperative recurrence after ileocolonic resection is common and identifying who is at higher risk helps guide postoperative monitoring and decisions about early prophylactic therapy.
Adult Crohn’s patients undergoing or recovering from ileocolonic resection; gastroenterologists and surgeons managing postoperative care; researchers studying recurrence prediction.
The study included 389 patients who had curative ileocolonic resection. Overall ePOR rate at 6–12 months was reported as 24.9%. Independent clinical risk factors for higher ePOR included prior exposure to biologics and low baseline serum albumin (<35 g/L).
Factors associated with lower risk were preoperative exclusive enteral nutrition and early postoperative prophylactic biologic therapy. Histopathological findings at the surgical margin—moderate-to-severe lymphoplasmacytic infiltration and lymphangiectasia—were strong predictors of ePOR.
A combined clinical-plus-pathology model (AUROC 0.829) performed better than a clinical-only model.
Retrospective design and single-country tertiary-center cohort may limit generalizability. The model showed good discriminatory performance but needs external validation before changing practice.
Review the original publication for the complete reporting, methods, and context.
Conflict statement: The authors declare that there are no conflicts of interest in this study.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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