ClinicalTrials.gov
Cure8 trial brief
Early Changes in Inflammatory Indices and Healing in IBD
Tests and monitoring
CRP
Colonoscopy
Clinical Trial Phase 1
Adult patients
Clinicians
Researchers
Newly Diagnosed
Why This Matters
Early, easily available blood markers that predict mucosal healing could help clinicians decide sooner whether a new or intensified therapy is working, potentially reducing prolonged ineffective treatment and guiding earlier adjustments.
Who Should Pay Attention
Adult patients with ulcerative colitis or Crohn's disease who are starting or escalating medical therapy; gastroenterologists and IBD clinicians; researchers studying biomarkers and treatment response.
Study Snapshot
Story typeClinical Reference
Evidence typeClinical trial
Enrollment138 participants
Study statusNot_yet_recruiting
Source depthTrial registry record
What To Know
This is a prospective cohort study (planned n=138) enrolling adults with confirmed UC or Crohn's disease who are starting or escalating medical therapy. Blood tests including CBC with differential, CRP, and serum albumin will be collected at baseline and at 4 weeks.
Participants will undergo follow-up colonoscopy with mucosal biopsies at ~12–16 weeks to assess endoscopic (Mayo 0 for UC, SES-CD <3 for CD) and histological healing. The study is currently listed as not yet recruiting and is observational; it will follow usual clinical care rather than assign experimental drugs.
Results, if positive, could support using early blood test changes as noninvasive markers of later mucosal healing, but the registry record does not contain results or timelines for publication.
Keep In Mind
This is a registry record for a not-yet-recruiting observational study; it does not report results. The protocol focuses on routine blood tests (CBC, CRP, albumin) and planned endoscopic/histologic outcomes at 12–16 weeks. As with any observational cohort, findings would need replication and validation before changing practice.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorAssiut University
Trial IDNCT07855055
Study typeObservational
Enrollment138 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedOct 2, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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