ClinicalTrials.gov
Cure8 trial brief
Why This Matters
Fibrotic strictures in Crohn’s disease often don’t respond to medication and may need endoscopic or surgical treatment. This trial directly compares two endoscopic options to see which is safer and more effective at immediately relieving small-bowel blockage.
Who Should Pay Attention
Adults with Crohn’s disease and small-bowel fibrotic strictures; gastroenterologists/endoscopists; clinical researchers in IBD interventions.
Study Snapshot
Story typeClinical Reference
Trial phaseNA
Enrollment244 participants
Study statusRecruiting
Source depthTrial registry record
What To Know
This is a registered, multicenter, randomized controlled trial comparing endoscopic stricturotomy (incising the fibrotic stricture) versus endoscopic balloon dilation for small-bowel fibrotic strictures in adults with Crohn’s disease.
The study’s primary outcome is procedure-related bleeding or perforation assessed during and immediately after the procedure; a secondary immediate outcome is technical success defined by whether the enteroscope can pass the treated stricture.
The trial is open-label and plans to enroll about 244 participants aged 18–70 with Crohn’s-related small-bowel strictures causing partial obstruction. Patients who meet exclusions (for example, anastomotic strictures, large ulceration at the site, marked angulation, or absolute surgical indications) are not eligible.
This record describes the trial design, interventions (endoscopic incision versus balloon dilation), and short-term safety/technical endpoints. It does not report results.
Keep In Mind
This is a registered, recruiting interventional trial record; no results are reported here. The primary outcome focuses on immediate procedure-related bleeding or perforation.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorSixth Affiliated Hospital, Sun Yat-sen University
Trial IDNCT07833332
Study typeInterventional
Trial phaseNA
Enrollment244 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedSep 22, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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