Surgical case reports
Cure8 research brief
Why This Matters
Family members can share similar Crohn’s disease patterns but still need individualized surgery and medication plans. If one twin or sibling has CD, early evaluation of symptoms in the cotwin can detect disease earlier and affect treatment choices.
Who Should Pay Attention
Patients with Crohn’s disease, family members/caregivers of people with IBD, colorectal surgeons, and IBD clinicians and researchers.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This article reports a case of presumed monozygotic twin brothers who both developed ileocolonic and perianal Crohn’s disease but underwent different surgical and postoperative medical treatments.
Twin 1 developed a perianal abscess at 16 and later required an anterior resection for fixed rectosigmoid stenosis and obstructive symptoms; biopsies showed epithelioid granulomas.
Twin 2 developed a perianal abscess at 18, had early ileocolonoscopy demonstrating terminal ileum and colorectal ulcers, received seton drainage for an intersphincteric fistula, and later had recurrent fistula drainage that improved after switching biologics from vedolizumab to adalimumab.
The report emphasizes prompt evaluation of a symptomatic cotwin, individualized surgical decision-making, and that biologic therapy choices may change over time depending on clinical course. Zygosity was reported by the family but not genetically confirmed.
Keep In Mind
Case report level evidence; zygosity was not genetically confirmed. The article summarizes clinical courses and management decisions rather than comparative outcomes. Summary grounded in the article abstract.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationSurgical case reports
AuthorsMatsunaga K, Matsuda K, Kotani T +5 more
Study typeJournal article, case reports, case Report
Indexed viaEurope PMC
Source typeResearch paper
PublishedNov 5, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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