PloS one
Cure8 research brief
Why This Matters
New, non-invasive biomarkers and AI-driven multi-omic approaches could make diagnosis and treatment of IBD more precise, helping patients avoid invasive tests and improving chances of choosing effective therapies sooner.
Who Should Pay Attention
Researchers developing IBD biomarkers, clinicians interested in precision medicine and monitoring tools, and patients curious about future diagnostic and treatment-prediction technologies.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This paper is a scoping review (PRISMA-ScR) of recent studies (2021–2025) that surveyed omics platforms (genomics, transcriptomics, proteomics, metabolomics, microbiomics), AI and biosensor approaches, and advanced imaging as candidate biomarkers for IBD.
The authors screened 784 records and included 27 articles; key themes highlighted metabolomic and gut microbiota signatures, genetic and epigenetic markers, and combining multi-omic data with AI to improve diagnostic and prognostic performance.
The review emphasizes potential clinical roles for these biomarkers in early diagnosis, monitoring disease activity, predicting progression, and forecasting therapeutic response. However, the included literature is limited in number and heterogeneous in methods, so findings are presented as promising directions rather than ready-for-clinic tests.
Keep In Mind
This is a scoping review of studies published 2021–2025; included studies are relatively few (27) and heterogeneous, so clinical implementation will require prospective validation and standardization.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationPloS one
AuthorsMatheus Querino da Silva, João Daniel de Souza Menezes, José Luis Esteves Francisco +27 more
InstitutionCenter for Studies and Development of Health Education - CEDES, São José do Rio Preto Medical School - FAMERP, Avenida Brigadeiro Faria Lima, São José do Rio Preto, São Paulo, Brazil.
Study typeJournal article, scoping review
Indexed viaPubMed
Source typeResearch paper
PublishedJul 13, 2026, 12:00 AM
Content availableJournal abstract
Conflict statement: The authors have declared that no competing interests exist.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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