Cure8 research brief
Many people with UC try dietary supplements; this randomized trial tested grape seed extract and found a measurable reduction in an inflammation blood marker (hs‑CRP) but no clear improvement in most other measured outcomes compared with placebo.
Adults with ulcerative colitis, clinicians who counsel patients on supplements, and researchers studying nutraceuticals, anti‑inflammatory supplements, or biomarker effects in IBD.
This randomized, triple‑blind, placebo‑controlled trial tested grape seed extract (GSE) 600 mg/day versus placebo for 12 weeks in 66 adults with mild‑to‑moderate ulcerative colitis.
The study found a larger drop in serum hs‑CRP in the GSE group vs placebo and a within‑group improvement in the clinical activity score (SCCAIQ) for GSE, but most other outcomes (IL‑17, ESR, gene expression differences between groups, and IBDQ‑9 quality‑of‑life scores) showed no significant between‑group benefit.
The trial was small (29 completers per arm) and enrolled patients with mild‑to‑moderate disease; the authors conclude larger trials with broader disease severity are needed. This report is based on the article abstract provided by Scientific Reports (full text extraction available).
Structured content depth: abstract — the brief is grounded in the study abstract provided by the journal. The trial was small and limited to mild‑to‑moderate UC; results do not establish clinical benefit and should not be taken as medical advice. The investigators call for larger, broader trials.
Review the original publication for the complete reporting, methods, and context.
Funding disclosed by the source: Iran University of Medical Sciences, award Grant numbers 26938
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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