Crystal Violet Staining for Colitis‐associated Neoplasia‐guided Delineation of Ulcerative Colitis‐associated Neoplasia for Endoscopic Submucosal Dissection: A Four‐case Report

What To Know

The paper is a four‑case report describing CV‑SCAN to highlight neoplastic areas not well seen with white‑light imaging. Targeted biopsy confirmed neoplasia, CV‑SCAN guided extent assessment, and ESD was used for resection.

Three cases had correspondence between CV‑positive areas and pathological extent with en bloc curative resection; one required a second ESD to remove residual disease that CV‑SCAN then identified. No procedure‑related adverse events or local recurrences were reported during follow‑up.

How to interpret: This is a small case series (four patients) reporting feasibility and potential utility of crystal violet staining as an adjunct to standard endoscopic imaging for delineating UC‑associated neoplasia prior to ESD.

It suggests CV‑SCAN may help detect residual neoplasia after initial resection, but larger studies are needed to confirm diagnostic accuracy and safety.