Cure8 research brief
If you have Crohn’s disease, upper GI biopsies showing focally enhanced gastritis or focally active inflammation could support a diagnosis of upper GI involvement and are associated with other histologic findings like granulomas and endoscopic ulcers.
Clinicians doing endoscopy or pathology for IBD, gastroenterology researchers studying biomarkers of UGI Crohn’s, and adults with Crohn’s disease who have upper GI symptoms.
The authors retrospectively reviewed endoscopy and biopsy specimens from 136 adult Crohn’s patients and report that about one-third had FEG and/or FAI on UGI sampling. Those with these features more often had granulomas and endoscopic ulcers compared with patients without FEG/FAI.
Gastric FAI and gastric granulomas were detected more often than in the esophagus or duodenum. The paper concludes that FEG and/or FAI might be useful auxiliary histologic indicators suggesting an increased likelihood of Crohn’s disease involvement of the upper GI tract, but calls for further controlled studies.
This appears to be a full peer-reviewed article in BMC Gastroenterology reporting a retrospective clinicopathological study. The summary here is grounded in the article abstract and metadata.
This is a retrospective single-cohort study with findings reported in the article abstract; the authors themselves note that controlled studies are needed to confirm diagnostic utility. The curated brief is based on the article’s abstract and full-text metadata.
Review the original publication for the complete reporting, methods, and context.
Funding disclosed by the source: National Key R&D Program of China, award 2023YFC2507300; Guangdong Provincial Health Commission Appropriate Technology Promotion Project, award 201905242108259876
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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