United European gastroenterology journal
Cure8 research brief
Why This Matters
The study connects a bothersome UC symptom (bowel urgency) to intestinal ultrasound signs of transmural inflammation, suggesting ultrasound might help explain and track symptom-related inflammation without relying solely on endoscopy.
Who Should Pay Attention
Patients with ulcerative colitis who have bowel urgency; gastroenterologists, sonographers, and researchers interested in noninvasive monitoring and symptom pathophysiology.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This single-centre prospective study enrolled 59 ulcerative colitis patients undergoing colonoscopy and compared those reporting bowel urgency with those who did not.
Patients with urgency had higher C‑reactive protein, worse endoscopic scores, greater bowel wall thickness in the descending colon, sigmoid colon, and rectum, and increased colour Doppler signal in the sigmoid and rectum.
Notably, thicker sigmoid submucosa and muscularis propria were associated with urgency, suggesting transmural involvement may contribute to the symptom. The study used transabdominal and transperineal ultrasound alongside colonoscopy and biomarker measurement (CRP). It was registered (UMIN000050099) and reports associations rather than proving causation.
Keep In Mind
This report is an abstract-level summary from a single-centre prospective study with 59 patients; results are associative and need confirmation in larger studies before clinical practice changes.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationUnited European gastroenterology journal
AuthorsSerizawa K, Sagami S, Umeda S +11 more
Study typeJournal article
Indexed viaEurope PMC
Source typeResearch paper
PublishedSep 1, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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