Cure8 research brief
Why This Matters
Strongyloides infection can look like IBD on symptoms and endoscopy/biopsy; missing it and giving immunosuppressants risks severe, potentially life-threatening hyperinfection. Recognizing this overlap helps avoid dangerous misdiagnosis.
Who Should Pay Attention
Clinicians evaluating suspected IBD (especially in endemic-area patients), adult patients with new inflammatory-diarrhea symptoms, and gastroenterology teams planning immunosuppression.
Study Snapshot
What To Know
A 52-year-old immunocompetent woman presented with persistent watery inflammatory diarrhea, marked hypokalemia, leukocytosis, and duodenal erosions. Multiple stool ova-and-parasite exams were negative, but duodenal biopsy revealed heavy eosinophilic infiltration and rhabditiform larvae morphologically consistent with Strongyloides stercoralis.
Molecular testing and serology were not performed, and the diagnosis relied on histology and parasitology review. She was treated with oral ivermectin plus adjunctive albendazole (the albendazole was an individualized, non-standard choice). Symptoms improved rapidly and she was well at one month.
Keep In Mind
Diagnosis here was based on duodenal histology demonstrating eosinophilia and larvae; stool tests were repeatedly negative and confirmatory molecular/serologic testing was not done. Treatment included ivermectin with an individualized addition of albendazole.
Source Details
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