Cure8 research brief
Findings show many patients in this Vietnamese tertiary center had advanced disease behavior at diagnosis and that endoscopy/biopsy findings were non-specific in a substantial minority, which is relevant to diagnostic delays and planning care.
Adults newly diagnosed with Crohn's disease, gastroenterologists and endoscopists, IBD researchers studying regional presentations or diagnostic criteria, and clinicians in Southeast Asia.
The study examined consecutive adults diagnosed between 2019–2024 using ileocolonoscopy with segmental biopsies and recorded Montreal classification, endoscopic appearances, and histology.
Common findings included terminal ileal involvement, skip lesions, and chronic inflammation on histology; classic endoscopic signs (longitudinal ulcers, cobblestoning) and granulomas were present in a minority.
Nearly half of patients had prior inconclusive colonoscopies and 25% had undergone intestinal resection before confirmed diagnosis, highlighting diagnostic challenges.
How this may affect you: These data suggest that Crohn's disease at diagnosis in this tertiary Vietnamese cohort often presents with advanced behavior (stricturing/penetrating) and that standard endoscopy/biopsy can be non-specific in a substantial minority.
This can help set expectations about diagnostic uncertainty and the need for careful, sometimes repeated evaluation.
Structured-content depth: abstract. This brief is grounded in the article abstract available on PubMed and does not reflect review of the full manuscript beyond the provided abstract.
Review the original publication for the complete reporting, methods, and context.
Conflict statement: This manuscript was prepared in accordance with the STROBE guidelines for observational studies.The authors declare no conflicts of interest.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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