ClinicalTrials.gov
Cure8 trial brief
ENhanced Recovery in CHildren Undergoing Surgery
Procedures and surgery
Phase 3 clinical trial
Pediatric Patients
Parents Caregivers
Clinicians
Researchers
Post Surgery Patients
Why This Matters
A structured ERP adapted for children could shorten hospital stays and improve recovery after pediatric GI surgery; this trial tested both clinical effectiveness and real-world implementation across many pediatric centers.
Who Should Pay Attention
Pediatric patients having elective gastrointestinal surgery and their caregivers; pediatric surgeons, anesthesiologists, perioperative nurses; researchers and hospital quality improvement teams.
Study Snapshot
Story typeClinical Reference
Trial phasePhase 3
Enrollment597 participants
Study statusCompleted
Source depthTrial registry record
What To Know
This trial enrolled pediatric patients at 18 U.S. hospitals and used a pragmatic stepped-wedge, cluster-randomized design to compare usual care versus a coordinated perioperative ERP that spans preadmission to post-operative care.
Key ERP components include patient counseling and education, limited fasting, tailored fluid management, early enteral intake and mobilization, reduced opioid use, and reduced routine use of drains/tubes.
The study focuses equally on effectiveness and on implementation using established implementation science frameworks and a Learning Collaborative to support uptake at participating sites.
Because the trial occurred in usual-care settings and drew on existing data sources (EHR), findings are intended to reflect real-world performance and barriers to broader adoption.
Keep In Mind
This is a clinicaltrials.gov trial record (phase 3, completed) describing design, interventions, and implementation approach — it does not report peer-reviewed outcomes in this entry. ERP effects can vary by site, resources, and how fully the protocol is implemented.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorNorthwestern University
Trial IDNCT04060303
Study typeInterventional
Trial phasePhase 3
Enrollment597 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedAug 7, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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