Cure8 trial brief
If a panenteric capsule can replace colonoscopy plus small-bowel imaging for initial diagnosis, it could offer a less invasive, single-test pathway for many people suspected of having Crohn's disease. That may reduce the need for multiple tests and speed diagnosis for younger adults.
Adults (18–40) with new or suspected Crohn's disease, gastroenterologists and endoscopists, IBD researchers, and patients interested in less invasive diagnostic options.
This registered interventional study is testing whether a single panenteric capsule endoscopy (camera pill) can provide a complete diagnostic assessment for people 18–40 years old with suspected Crohn's disease, compared with the traditional pathway of colonoscopy plus a small-bowel exam (MRI enterography or small-bowel capsule).
The trial will measure whether the initial test(s) yield a complete gastrointestinal assessment and an unambiguous diagnosis without needing supplementary exams.
Participants are randomized to either a minimally invasive diagnostic algorithm using panenteric capsule endoscopy or to the traditional work-up (ileocolonoscopy plus MRI enterography or small-bowel capsule).
Key eligibility requirements include clinical suspicion of Crohn's disease and elevated fecal calprotectin or supportive inflammatory markers; people with prior intestinal resection, active suspected bowel obstruction, pregnancy, or certain positive infectious/serologic tests are excluded.
The study is recruiting in Denmark and Sweden with a planned enrollment of 165. This is a trial record (interventional) registered on ClinicalTrials.gov; it reports design, interventions, primary outcome (diagnostic completeness), and inclusion/exclusion criteria but does not present results.
This is a registered interventional study that is currently recruiting and does not report outcomes. The record describes planned methods and eligibility; it is not a peer-reviewed result. The trial focuses on diagnostic completeness immediately after the initial procedure(s) rather than long-term outcomes.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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