NIH RePORTER
Cure8 regulatory brief
Gastrointestinal tissue-adapted eosinophils in health and disease
Research and clinical trials
Basic Science
Researchers
Clinicians
Inflammatory bowel disease
Crohn's disease
Why This Matters
This project aims to understand how gut-adapted eosinophils support immune homeostasis or drive pathology in conditions that include IBD and eosinophilic GI disorders, with the goal of enabling more precise eosinophil-targeted therapies.
Who Should Pay Attention
Researchers in mucosal immunology and eosinophil biology; clinicians treating IBD and EGID; translational scientists interested in immune-modulating therapies.
Study Snapshot
Story typeRegulatory
Evidence typeFunded research project
Study statusFunded
Source depthResearch project record
What To Know
The project uses high-dimensional flow cytometry, unsupervised clustering, in vivo mouse models, and translational studies of human tissues to define receptor signatures and surface proteomes of intestine-adapted eosinophil subsets.
Early data suggest gut-specific imprinting (including an inhibitory C-type lectin) that restrains eosinophil activation in healthy tissue but is altered in inflamed states.
The research will test mechanisms by which eosinophils regulate intraepithelial lymphocyte populations and examine whether similar receptor signatures appear in human EGID and related conditions.
Keep In Mind
This is a funded NIH project record describing planned and ongoing basic and translational research. It is not a peer-reviewed publication reporting final results; interpretive and therapeutic implications are preliminary until studies are completed and published.
Source Details
Review the original publication for the complete reporting, methods, and context.
Funded research project
Evidence type derived from source or registry metadata.
PublicationNIH RePORTER
AuthorsLisa Ann Spencer
InstitutionUNIVERSITY OF COLORADO DENVER
Study typeFunded Research Project
Indexed viaNIH RePORTER
Source typeFunded research record
PublishedSep 1, 2026, 12:00 AM
Content availableResearch project record
Funding disclosed by the source: National Institute of Allergy and Infectious Diseases - R01AI192412 - $771,983
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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