Cure8 research brief
LCH can present like perianal Crohn's disease and may be missed if biopsies and molecular testing are not performed. Correct diagnosis changes treatment and prompts systemic staging for other malignancies.
Clinicians treating refractory perianal/colonic disease; adult IBD patients with atypical or non-healing perianal lesions; gastroenterologists and colorectal surgeons.
This case report describes an woman in her early 80s with chronic anal fissures concerning for perianal Crohn's disease; colonoscopy and biopsies showed LCH confirmed by BRAF V600E mutation. Systemic staging found unrelated breast and kidney malignancies. The patient received cladribine chemotherapy with resolution of LCH lesions and symptoms.
Histology and molecular profiling were key to diagnosis and to guide therapy.
This content is an abstract-level case report from BMJ Case Reports. It describes one older adult patient; results are not broadly generalizable. The diagnosis relied on histology and detection of BRAF V600E. Treatment choice and outcomes reflect this single patient.
Review the original publication for the complete reporting, methods, and context.
Conflict statement: Competing interests: None declared.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
After bowel resection, Crohn’s often returns quietly at the surgical join (anastomosis). Early, planned monitoring can detect inflammation before symptoms appear and help prevent symptomatic recurrence or repeat surgery.
Risk stratification helps identify people with Crohn's who are more likely to develop strictures, fistulas, or need surgery so clinicians can monitor and treat them more aggressively early on. Objective tests like fecal...
Cure8 found this source from youtube.com, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Colonoscopy. Open the original article for the full details.
