Cure8 trial brief
Chronic pain is common in people with Crohn’s disease and ulcerative colitis and can persist despite controlling gut inflammation. Brief online pain-education programs could offer a low-burden, scalable way to reduce pain interference and improve quality of life if they prove feasible and helpful.
Adults with Crohn’s disease or ulcerative colitis experiencing chronic pain; clinicians and researchers interested in nonpharmacologic, digital pain-management strategies for IBD.
This trial compares two brief, online pain-education approaches delivered once (2-hour session or recorded 2-hour video) plus a relaxation audio app versus an alternative online program. The main outcome is pain interference measured by PROMIS weekly for 8 weeks.
Key eligibility requirements include physician-confirmed Crohn’s disease or UC, ≥3 months of IBD-related chronic pain, PROMIS Pain Interference T-score ≥60, medical stability, no standing opioids, and no recent/planned major IBD treatment changes.
The interventions focus on cognitive-behavioral and pain neuroscience education, mindfulness and self-management strategies; they are scalable, brief, and intended to be used at home on an internet-enabled device.
This is a registered interventional pilot trial (NOT_YET_RECRUITING) describing planned interventions and outcomes; it does not report results. The sample is small and excludes people on chronic opioids or with imminent IBD treatment changes, so generalizability will be limited.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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