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Small Intestinal Extranodal Marginal Zone... : ACG Case Reports Journal - Ovid
Procedures and surgery
Colonoscopy
Fecal calprotectin
Imaging
Case Report
Inflammatory bowel disease
Crohn's disease
Why This Matters
Some cancers of the small intestine can look like Crohn’s disease. If symptoms don’t fit typical IBD patterns or don’t respond as expected to therapy, re-evaluation may be needed to avoid delays in diagnosis and treatment.
Who Should Pay Attention
Patients newly diagnosed with IBD or with treatment-refractory disease, gastroenterologists, IBD clinicians, and pathologists.
Study Snapshot
Story typeResearch paper
Evidence typeCase report
Source depthFull source text
What To Know
This is a full-text case report describing a 23-year-old woman who was initially diagnosed and treated as Crohn’s disease but was later found to have primary small intestinal extranodal marginal zone (MALT) lymphoma.
The report details the clinical course, lab abnormalities (including monoclonal protein and raised beta-2 microglobulin), endoscopic and imaging findings, biopsy/immunohistochemistry results (CD20/CD138 positivity with light-chain restriction), and staging consistent with primary GI lymphoma.
The case emphasizes that primary intestinal lymphoma can closely mimic Crohn’s disease—clinically, endoscopically, and histologically—and that transient responses to steroids or biologics do not rule out malignancy.
The authors highlight the need to reconsider the diagnosis when IBD is refractory or when atypical features (marked malabsorption, monoclonal protein, prominent systemic features) are present. For readers: this is a single case report, not a study of outcomes or treatments.
The diagnostic details are taken from the published case narrative and pathology/imaging described in the article.
Keep In Mind
This is a single case report from an academic journal describing one patient’s course; findings do not imply how common this misdiagnosis is. The diagnosis was supported by imaging, endoscopy, and immunohistochemistry from biopsy—see the original article for full pathology details.
Source Details
Review the original publication for the complete reporting, methods, and context.
Publicationovid.com
Indexed viaGoogle News
Source typeWeb article
PublishedAug 23, 2026, 2:11 AM
Content availableFull source text
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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