European journal of pediatrics
Cure8 research brief
Why This Matters
Families and clinicians often wonder whether H. pylori infection in childhood affects risks for asthma, IBD, celiac disease, or other immune-mediated disorders.
This paediatric-focused review shows no clear overall protective or harmful association for asthma and inconsistent evidence for other immune conditions — so current data do not justify changing care based on H. pylori status alone.
Who Should Pay Attention
Pediatric patients and their parents/caregivers, pediatric gastroenterologists, allergists, and researchers studying microbiome–immune interactions in children.
Study Snapshot
Story typeResearch paper
Evidence typeSystematic review
Source depthJournal abstract
What To Know
The review focused specifically on paediatric studies from the past 12 years and assessed bias with ROBINS-E. For asthma, pooled results did not show a significant association overall. Subgroup findings varied by diagnostic method and study bias, so the apparent protective signal was not consistent across higher-quality or histology-based studies.
The review also summarised mixed and inconsistent results across celiac disease, IBD, and EoE — meaning current paediatric evidence does not support firm conclusions about H. pylori's role in those conditions. The authors call for more prospective paediatric research to clarify potential immune-modulating effects of H. pylori.
Keep In Mind
Results are based on a systematic review and meta-analysis of paediatric studies from the past 12 years; subgroup differences by diagnostic method and study bias raise uncertainty. The source is an abstract from a peer-reviewed journal; it summarises pooled evidence but heterogeneity limits definitive conclusions.
Source Details
Review the original publication for the complete reporting, methods, and context.
Systematic review
Evidence type derived from source or registry metadata.
PublicationEuropean journal of pediatrics
AuthorsMarta Tavares, André Ferreira, Ema Campo +3 more
InstitutionPaediatric Gastroenterology Unit, Paediatrics Department, Child and Adolescent Health Division, Unidade Local de Saude de Santo António Porto, Largo da Maternidade de Júlio Dinis 17, 4050-651, Porto, Portugal. mdtavares@gmail.com.
Study typeJournal article, systematic review, meta Analysis, review
Indexed viaPubMed
Source typeResearch paper
PublishedOct 19, 2026, 12:00 AM
Content availableJournal abstract
Conflict statement: Declarations. Competing interests: The authors declare no competing interests.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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