ClinicalTrials.gov
Cure8 trial brief
Inflammatory Biomarkers and Disease Activity in Inflammatory Bowel Disease
Tests and monitoring
Biomarkers
Biomarker
Colonoscopy
Clinical Trial Phase 1
Adult patients
Clinicians
Researchers
Why This Matters
Non-invasive, inexpensive blood-derived ratios could offer easier, more frequent assessment of IBD activity than repeat endoscopy. This study evaluates several such ratios (CAR, PAR, NLR, FAR, Hb/CRP) against clinical and endoscopic activity.
Who Should Pay Attention
Adult IBD patients, gastroenterologists/IBD clinicians, and researchers focused on biomarkers or disease monitoring
Study Snapshot
Story typeClinical Reference
Evidence typeClinical trial
Enrollment120 participants
Study statusNot_yet_recruiting
Source depthTrial registry record
What To Know
This is a cross-sectional, not-yet-recruiting observational study at Assiut University enrolling adults with established Crohn's disease or ulcerative colitis.
Investigators will collect routine clinical activity scores (Mayo scores for UC; CDAI/HBI for Crohn's) and standard laboratory tests (CBC, CRP, albumin, fibrinogen) to calculate multiple inflammatory ratios and compare them to clinical and, when available, endoscopic disease activity.
The primary outcome is the diagnostic accuracy (AUC) of the CRP-to-albumin ratio for discriminating active disease versus remission, with planned secondary assessments of other ratios. The study does not test an intervention and will not by itself change clinical guidelines, but could add evidence about low-cost monitoring tools.
Keep In Mind
This is an observational, cross-sectional study registered on ClinicalTrials.gov and listed as not yet recruiting. Results are prospective but the design evaluates diagnostic accuracy rather than testing a treatment; findings would need replication before changing practice.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorAssiut University
Trial IDNCT07788131
Study typeObservational
Enrollment120 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedAug 26, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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