Cure8 research brief
This scoping review summarizes prevalence and demographic patterns of upper-gastrointestinal Crohn’s in adults, showing variable but non-negligible rates that depend on diagnostic approach. Standardization could change how often upper-GI disease is detected and reported.
Clinicians, researchers, and adult patients interested in Crohn’s disease distribution and diagnosis
This scoping review pooled adult studies up to Nov 2025 to summarize how often Crohn’s disease involves the upper GI tract. Across 95 cohorts with prevalence data the median reported prevalence of adult upper-GI Crohn’s was 8.8% (IQR 3.99%–14.5%); isolated upper-GI disease was uncommon (~1.4%).
Studies that used systematic endoscopy and biopsy reported higher rates than population-based cohorts. The review highlights inconsistent definitions and detection methods across studies and geographic/ethnic variation in reported prevalence.
Summary is based on the article abstract (scoping review). Primary studies included used heterogeneous definitions and detection strategies; prevalence estimates vary by study design and geography.
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This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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