European journal of gastroenterology & hepatology
Cure8 research brief
Why This Matters
The study examines whether recommended management for rectal inflammation in UC is followed in routine care and whether following guidelines affects 12-month remission — important for patients and clinicians aiming for timely, effective treatment.
Who Should Pay Attention
Clinicians who perform endoscopy and treat ulcerative colitis, adult patients with rectal-dominant UC or ulcerative proctitis, and healthcare teams interested in care pathways and quality improvement.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This 2022–2024 single-center retrospective cohort looked at real-world adherence to British Society of Gastroenterology (BSG) recommendations for managing endoscopic rectal activity (ulcerative proctitis/rectal disease) and measured clinical, biochemical, endoscopic, and histological remission at 12 months.
About half of 119 patients received guideline-adherent management. Decisions made at the time of endoscopy were much more likely to follow guidelines than decisions deferred to clinic. Overall remission rates were high, and guideline adherence showed numerically higher clinical remission but without statistical significance.
The study highlights that endoscopy-led decision-making is a modifiable care-delivery factor linked to better adherence; however, adherence alone may not fully capture quality because outcomes were generally favorable. This brief is based on the article abstract provided by the journal; Cure8 has not reviewed the full article beyond the supplied text.
Keep In Mind
This is a single-center, retrospective observational study using an abstract-level summary. Results show associations but cannot prove causation; the abstract does not provide detailed subgroup analyses or full methods. Endoscopy-timed decisions were associated with higher guideline adherence, but remission differences were not statistically significant.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationEuropean journal of gastroenterology & hepatology
AuthorsMalkopoulos A, Subhaharan D, James R +3 more
Study typeIm, journal article
Indexed viaEurope PMC
Source typeResearch paper
PublishedJun 2, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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