ClinicalTrials.gov
Cure8 trial brief
Why This Matters
Diet can change gut microbes and their metabolites; this trial tests whether a high-protein, high-fiber diet can lower a microbe-derived compound (H2S) thought to be relevant in UC. If effective, diet-based approaches could offer a non-drug strategy to modify disease-related microbial activity.
Who Should Pay Attention
Adults with ulcerative colitis, clinicians/dietitians treating IBD, researchers interested in microbiome-targeted dietary interventions.
Study Snapshot
Story typeClinical Reference
Trial phaseNA
Enrollment40 participants
Study statusNot_yet_recruiting
Source depthTrial registry record
What To Know
This ClinicalTrials.gov record describes a planned interventional study testing a high-protein, high-fiber (HPHF) diet in adults with ulcerative colitis (UC).
The diet is designed to meet elevated protein needs while reducing colonic microbial hydrogen sulfide (H2S) production; frozen meals are provided and participants follow alternating weeks of standard and HPHF diet across a 4-week on-off cycling schedule.
The trial is not yet recruiting, plans to enroll about 40 adults with mild UC (UCEIS ≤4), and will assess fecal H2S production from stool samples at week 4 as a primary outcome. This entry is a trial record summary based on the ClinicalTrials.gov registry information; it describes the planned study design and eligibility but does not report results.
Keep In Mind
Registry entry describes planned eligibility, interventions, and a primary biomarker outcome (fecal H2S). No results are reported; the trial is not yet recruiting.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorUniversity of Minnesota
Trial IDNCT07520461
Study typeInterventional
Trial phaseNA
Enrollment40 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedAug 5, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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