JGH open : an open access journal of gastroenterology and hepatology
Cure8 research brief
Why This Matters
Many patients and clinicians assume terminal ileitis on imaging means Crohn's disease. This study suggests that, after further testing, most CT-detected terminal ileitis is due to non-Crohn's causes, so thorough evaluation is important.
Who Should Pay Attention
Clinicians evaluating imaging-detected ileitis, gastroenterologists, researchers, and patients being investigated for possible Crohn's disease
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
The study reviewed CT reports from a single tertiary center over a 10-year period and then examined clinical follow-up including stool testing, endoscopy, and histology. Infectious and surgical causes were more common than CD among patients with CT terminal ileitis.
Endoscopy was performed in fewer than half of patients; when biopsies were taken, histologic inflammation was present in under half of those cases. Lower albumin stood out as a predictor of CD in multivariable analysis, while routine inflammatory markers were less helpful.
The authors conclude that CT terminal ileitis only infrequently indicates Crohn's disease and that a careful diagnostic workup (including stool testing and endoscopy) is important.
Keep In Mind
The summary is grounded in the article abstract. The study is retrospective from a single tertiary hospital and used clinical follow-up, stool testing, endoscopy, and histology; prospective studies are needed to confirm findings.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationJGH open : an open access journal of gastroenterology and hepatology
AuthorsIrene Lu, Carl Cosgrave, Phongsakone Inthavong +4 more
InstitutionDepartment of Gastroenterology Barwon Health Geelong Victoria Australia.
Study typeJournal article
Indexed viaPubMed
Source typeResearch paper
PublishedAug 10, 2026, 12:00 AM
Content availableJournal abstract
Conflict statement: The authors declare no conflicts of interest.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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