Minerva obstetrics and gynecology
Cure8 research brief
Why This Matters
People with IBD often worry whether their disease affects fertility or embryo health. This study directly looks at embryo chromosomal normality during IVF and found similar euploidy rates in patients with and without IBD, which may be reassuring.
Who Should Pay Attention
Patients with inflammatory bowel disease (Crohn’s disease or ulcerative colitis) considering IVF or PGT-A, reproductive endocrinologists, fertility counselors, and researchers studying fertility outcomes in chronic inflammatory conditions.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This study compared embryo chromosomal normality (euploidy) in patients with inflammatory bowel disease (Crohn’s disease or ulcerative colitis) versus matched controls undergoing IVF with PGT-A at a single academic center. The authors report identical euploid blastocyst rates (47.5% vs.
47.5%) and no significant differences in aneuploid or mosaic embryo rates. Patients with IBD had higher total and mature oocyte yields, but fertilization, blastulation, and maturity rates were similar. The analysis was retrospective and included 43 patients with IBD and 129 controls treated between 2011 and 2022.
Interpretation is limited by the small, retrospective cohort and potential unmeasured confounders. The authors state their results offer some reassurance that IBD may not reduce embryo chromosomal competence, but they call for prospective studies to confirm these findings.
If you have IBD and are considering IVF, this study suggests embryo aneuploidy rates may be similar to people without IBD, but individual factors (disease activity, treatments, age, and fertility history) still matter and should be discussed with your reproductive specialist.
Keep In Mind
This is a single-center, retrospective cohort with a modest sample size (43 IBD patients). The study excluded certain infertility causes and used next-generation sequencing PGT-A, but it cannot rule out smaller effects or impacts of specific IBD therapies or disease activity. Prospective, larger studies are needed.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationMinerva obstetrics and gynecology
AuthorsAtoosa Ghofranian, Samantha L Estevez, Diana S Shaari +6 more
InstitutionIcahn School of Medicine at Mount Sinai, New York, NY, USA - atoosagmd@gmail.com.
Study typeJournal article
Indexed viaPubMed
Source typeResearch paper
PublishedSep 7, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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