Cure8 news brief
Most people with IBD can have children safely with modern treatments and planning; uncontrolled disease poses greater risks to pregnancy than continuing most IBD medications. Planning and specialist input before conception improve outcomes.
People with IBD considering pregnancy, pregnant patients with IBD, partners/caregivers, gastroenterologists and obstetric clinicians.
This article reviews contemporary evidence and guidance about IBD and pregnancy. It highlights that Crohn’s disease and ulcerative colitis affect about 1% of Canadians and that outdated advice discouraging pregnancy is no longer appropriate.
The author summarizes key findings from large observational studies (notably the PIANO study) and a 2025 global consensus recommending continuation of most IBD medications during pregnancy and breastfeeding, while noting clear exceptions (methotrexate and some newer JAK inhibitors and S1P modulators).
The article emphasizes planning: aim for disease remission before conception, discuss medication adjustments with your gastroenterologist, and use objective monitoring (blood, stool tests, imaging, and selective colonoscopy) during preconception and pregnancy.
It also notes that about 40% of people with IBD may flare during pregnancy and that uncontrolled disease is linked to preterm birth and low birth weight. Keep communication open with your IBD team; preconception counselling and close monitoring during pregnancy improve chances of a healthy outcome.
The article is a clinical-review style piece summarizing cohort studies (e.g., PIANO) and a 2025 global consensus; it is not a report of a new trial. Medication guidance reflects current consensus and observational evidence; some newer drugs are excluded due to animal-safety concerns.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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