Cure8 research brief
Pregnant people with IBD or other autoimmune diseases often face tough choices about continuing biologics or JAK inhibitors. CARE-HP aims to produce broader, disease-specific evidence to help patients and clinicians weigh maternal and infant risks and benefits.
Pregnant patients with autoimmune disease (including IBD/Crohn's), clinicians who manage pregnancy in immunemediated disease, researchers in pharmacoepidemiology and pregnancy safety, and caregivers/parents.
CARE-HP will leverage existing infrastructure and insurance records for millions of pregnancies (including >92,000 among people with autoimmune diseases) and use a two-step approach of broad data-mining followed by confirmatory studies.
The team plans disease-specific and drug-class–specific comparisons, head-to-head within advanced therapy classes or versus conventional therapies, and analyses of continuation versus discontinuation during pregnancy.
The project will prioritize maternal outcomes (pregnancy loss, preterm birth, flares, hospitalization, serious infection, preeclampsia) and infant outcomes (congenital malformations, small for gestational age, serious infections, ASD, ADHD), using methods to address confounding and treatment-effect heterogeneity.
This is a project-record from NIH Reporter describing planned/funded research (project aims and methods). It does not present results; conclusions will depend on the confirmed analyses that follow the initial data-mining signals.
Review the original publication for the complete reporting, methods, and context.
Funding disclosed by the source: Eunice Kennedy Shriver National Institute of Child Health and Human Development - R01HD123733 - $703,092
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
Keeping IBD well controlled before and during pregnancy lowers the risk of adverse outcomes for both parent and baby; understanding which medications are safe and which should be stopped is crucial for family planning.
Most people with IBD can have children safely with modern treatments and planning; uncontrolled disease poses greater risks to pregnancy than continuing most IBD medications. Planning and specialist input before...
Women with Crohn’s can face specific reproductive, sexual, and body-image issues that affect quality of life and pregnancy planning. Understanding how disease activity and medications interact with fertility and...
