Journal of Clinical Medicine
Cure8 research brief
Why This Matters
NLH of the terminal ileum can look like Crohn’s disease on endoscopy; biopsy and histology are important to distinguish benign reactive NLH from inflammatory bowel disease or malignancy.
The reported link between Giardia infection and higher fecal calprotectin is preliminary but may point to infectious contributors to ileal inflammation.
Who Should Pay Attention
Adult patients undergoing evaluation for terminal ileal lesions, gastroenterologists/endoscopists, pathologists, and researchers interested in ileal inflammation, biomarkers, or intestinal infections.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
The authors reviewed adults who had terminal ileal biopsies for suspected NLH between 2023–2025. Of 64 biopsied patients, 50 (78%) had histologic confirmation; 43 with complete data were analyzed. Diarrhea and abdominal pain were the most common presenting symptoms. Routine histology findings were predominantly reactive without features of lymphoma.
One patient whose endoscopy looked like Crohn’s disease was later diagnosed with Crohn’s, indicating that endoscopic appearance alone may not reliably distinguish NLH from IBD.
The study also explored an association between Giardia lamblia infection and higher fecal calprotectin levels; this was an exploratory finding that the authors say needs confirmation in further research.
Keep In Mind
Retrospective single-center design and small sample size limit generalizability. The structured content depth is an abstract; Cure8’s brief is grounded in the article abstract provided and does not reflect a full independent review of the complete study.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationJournal of Clinical Medicine
AuthorsÜmit Karabulut, Ahmet Yavuz, Çiğdem BUDAK ECE +1 more
InstitutionSağlık Bilimleri Üniversitesi
Study typeArticle
Indexed viaOpenAlex
Source typeResearch paper
PublishedNov 9, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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