Cure8 research brief
Coexistence of ulcerative colitis and collagenous colitis is rare but can change diagnosis and management. Stool calprotectin and biopsies helped identify and monitor disease activity, and adjusting mesalazine coincided with biomarker improvement.
Adult patients with IBD or unexplained colitis, gastroenterologists, pathologists, and clinicians who interpret colonoscopy biopsies and fecal calprotectin results.
A 51-year-old woman underwent colonoscopy after a positive fecal occult blood test. Biopsies from multiple colonic segments showed features of active UC (architectural distortion, basal plasmacytosis, crypt abscesses) alongside a diagnostic subepithelial collagen band (15–23 µm) consistent with collagenous colitis.
Stool calprotectin was elevated (77.4 mg/kg initially, rose to 1779 mg/kg at three months) and later normalized (77 mg/kg) after optimization of mesalazine (mesalamine) therapy, suggesting the biomarker tracked mucosal inflammation and treatment response in this case.
The authors review prior reports of synchronous or metachronous coexistence of UC and collagenous colitis and emphasize considering coexisting diagnoses when histology is complex, even if the patient has few or no symptoms.
This record is an individual case report (abstract-level summary). Single cases show what is possible but do not establish how commonly two colitis types coexist or the best treatment approach. The report uses serial fecal calprotectin and histology to document disease activity and response.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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