Cure8 research brief
FMT is shown here to be an effective option for treating recurrent C. difficile infection, including for patients who also have IBD — a group often vulnerable to recurrent infections and complications.
Adults with recurrent C. difficile infection; patients with IBD; gastroenterologists and clinicians managing rCDI; researchers studying microbiome therapies.
The paper analyzed 75 patients treated with FMT after at least two CDI recurrences; follow-up data were available for 65 patients and 86.1% achieved sustained remission (absence of diarrhea) at three months. Donor screening followed German BfArM requirements.
FMT was delivered by colonoscopy, oral capsules, or both; route of administration did not change outcomes. Adverse events were uncommon and mainly self-limiting. Patients with IBD (15 in this cohort) had a similar response rate to the overall group.
The study focuses on effectiveness and short-term safety in a real-world single-center setting and uses absence of diarrhea as a clinical surrogate for recurrent CDI.
Retrospective single-center design and three-month follow-up limit generalizability and long-term safety assessment. The primary endpoint was absence of diarrhea as a surrogate for recurrence; diagnostic testing details for CDI recurrence were not specified in the abstract.
Review the original publication for the complete reporting, methods, and context.
Conflict statement: Andreas Stallmach has received lecture fees from Abbvie, A. Nissle-Gesellschaft, Bristol Myers Squibb, Celltrion, Falk Foundation, Ferring, GSK, Johnson&Johnson, Kompetenznetz Darmerkrankungen, Lilly, MedUpdate, Takeda and consulting fees from Abbvie, Amgen, Astra zeneca, Gilead, GSK, Johnson&Johnson, Lilly, MSD, Roche, Roland Berger, Pfizer, Takeda, Tillots Pharma. All other authors report no conflict of interests.
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