ClinicalTrials.gov
Cure8 trial brief
Why This Matters
Understanding how individual diet and microbiome patterns relate to disease activity could help create personalized dietary approaches for children with Crohn's disease and improve monitoring using home fecal calprotectin and digital dietary tracking.
Who Should Pay Attention
Pediatric patients with newly diagnosed Crohn's disease, their families and caregivers, pediatric gastroenterologists, and researchers studying the microbiome, biomarkers, and personalized nutrition approaches.
Study Snapshot
Story typeClinical Reference
Evidence typeClinical trial
Enrollment267 participants
Study statusActive_not_recruiting
Source depthTrial registry record
What To Know
This study will follow pediatric participants for one year and collect stool for metagenomic sequencing, home fecal calprotectin tests, blood samples, anthropometrics, dietary logs via a smartphone app, and clinical data from endoscopies that are done for clinical care (not performed by the study).
Researchers plan to use machine learning on the combined dataset to build a personalized nutrition predictor intended to guide tailor-made dietary regimens for pediatric CD. The registry lists three arms: newly diagnosed CD, children undergoing colonoscopy for non-inflammatory complaints, and non-invasively characterized healthy controls.
Practical point: this is an observational cohort (not an interventional diet trial); its goal is to generate predictive algorithms and hypotheses that could inform future personalized dietary interventions.
Keep In Mind
This is an observational, non-interventional study (ACTIVE_NOT_RECRUITING) that will collect data over one year and aims to build predictive algorithms; it does not itself test a specific dietary treatment. Registered procedures include endoscopies only when clinically indicated. As a trial registry entry, results are not reported here.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorWeizmann Institute of Science
Trial IDNCT04283864
Study typeObservational
Enrollment267 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedSep 29, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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