Cure8 trial brief
Mental health symptoms are common in people with IBD and may be influenced by both psychological and biological factors. A virtual, group psychotherapy program tailored to IBD could increase access to treatment and help address anxiety and depression while studying links between mental health and disease biology.
Adults with Crohn’s disease or ulcerative colitis who have moderate-or-higher anxiety or depression, caregivers of adults with IBD, clinicians treating IBD-related mental health, and researchers interested in brain–gut and biomarker links in IBD.
This study is testing whether a structured, 10-session virtual group CBT-based program tailored for people with IBD is acceptable and feasible for those with clinically significant anxiety or depression.
The intervention includes psychoeducation about the brain–gut connection, behavioral activation, cognitive restructuring, and relapse-prevention skills, delivered in 120-minute group sessions guided by the Mind Over Mood manual.
Researchers will also collect blood and stool samples to compare disease activity and tryptophan metabolites with mental health symptoms, linking psychosocial outcomes to biological measures. The trial plans to enroll 16 adults and is not yet recruiting; participation requires English fluency and a PHQ-9 or GAD-7 score ≥10.
If you’re considering participation, expect a mix of virtual therapy sessions and a few in-person study visits for sample collection and assessments; details like exact schedule, compensation, and travel logistics will be provided by the study team.
This is a small, early feasibility trial (planned n=16) that focuses on acceptability and feasibility rather than proving efficacy. It is not yet recruiting; results are not available. The trial includes biomarker collection (blood/stool) but is exploratory in nature. Participation requires English fluency and screening scores indicating moderate symptoms.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
Self‑management programs delivered by nurses may help people with IBD improve daily functioning, confidence in managing their condition, and quality of life even when inflammation markers don’t change. That matters...
Stigma is common in people with IBD and can worsen isolation, anxiety, and quality of life. Practical coping strategies and support resources can help reduce emotional burden and improve daily functioning.
People with IBD face higher rates of anxiety, depression and other psychiatric disorders that often begin years before diagnosis and can persist long term. Recognizing and treating mental-health issues early can improve...
