Cure8 research brief
Both EEN and the Crohn’s disease exclusion diet are used to induce remission in children with Crohn’s disease. Evidence that they perform similarly through 52 weeks may help families and clinicians choose the approach that best fits a child’s circumstances and preferences.
Pediatric patients with Crohn’s disease and their parents/caregivers, pediatric gastroenterologists and dietitians, and clinicians considering dietary induction strategies.
This study included 159 pediatric patients (75 EEN, 84 CDED) treated between 2014–2023 and followed for 52 weeks. At week 6, remission rates, treatment adherence, normalization of C-reactive protein, and fecal calprotectin <150 µg/g were similar between groups.
Throughout 52 weeks there were no clear differences in exacerbations, corticosteroid or biologic use, hospitalizations, or surgeries.
How people might use this: For families and clinicians deciding between EEN and CDED for remission induction, this cohort suggests both approaches can achieve similar short-term remission and similar medium-term clinical outcomes. Decisions may therefore consider patient preference, feasibility, and local practice.
Limitations and tone: This is a historical (observational) cohort rather than a randomized trial; that affects certainty about cause and effect. The abstract-level summary here is grounded in the source-provided abstract.
This is a historical cohort study (non-randomized) using data from 2014–2023 and summarized here from the journal abstract. That design can be affected by selection bias and unmeasured differences between groups; randomized trials provide stronger causal evidence.
Review the original publication for the complete reporting, methods, and context.
Funding disclosed by the source: None
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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