JCEM case reports
Cure8 research brief
Why This Matters
Severe UC flares can produce extreme but reversible hyperglycemia that may look like new-onset diabetes, so patients and clinicians should monitor and re-evaluate glucose over time rather than assuming a permanent diagnosis immediately.
Who Should Pay Attention
Adults with UC/IBD in severe flare, gastroenterologists, endocrinologists, inpatient care teams
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
A 56-year-old man with no prior diabetes developed profound hyperglycemia (603 mg/dL) and an elevated HbA1c (9.4%) during a UC flare. Workup showed preserved insulin secretion, insulin resistance, negative autoimmune markers, and imaging without pancreatic disease. Colonoscopy and biopsy confirmed active moderate UC.
He received intravenous corticosteroids and temporary insulin; blood glucose rapidly normalized and insulin was stopped. At 3 months after remission his HbA1c returned to normal (4.7%).
This case highlights that marked hyperglycemia can be inflammation-driven and reversible, so repeated assessment over time is important before labeling someone with chronic diabetes.
Keep In Mind
Single-case evidence: illustrates plausibility but not frequency. The report documents steroid treatment and insulin were used; causality between steroid use and hyperglycemia is possible but the hyperglycemia was present on presentation and resolved after remission follow-up.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationJCEM case reports
AuthorsHitam Hagog Natour, Michal Kasher Meron, Pnina Rotman-Pikielny +1 more
InstitutionInstitute of Endocrinology, Diabetes and Metabolism, Meir Medical Center, Kfar Saba 4428164, Israel.
Study typeCase reports, journal article
Indexed viaPubMed
Source typeResearch paper
PublishedSep 11, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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