Evidence types
Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.
Page 5 of 15 · 709 articles
Cure8 found this source from bioengineer.org, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. Open the original article for the...
Non-invasive imaging biomarkers that track intestinal inflammation and structure could speed preclinical testing of IBD therapies and guide translational imaging research relevant to clinical monitoring of ulcerative...
Researchers have found a short peptide in potato protein with antioxidant and anti-inflammatory properties and are testing it as a possible oral treatment for intestinal inflammation — a potential new, plant-derived...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from American journal of...
The study connects many IBD genetic risk regions to specific genes and cell types, helping prioritize drug targets. It also nominates a known small molecule (entrectinib) as a repurposing candidate via NLRP3/NEK7...
Preclinical data suggest blocking STAT3 with TTI-101 prevented colitis-associated colorectal tumors in a mouse model and altered tumor-related gene expression and the gut microbiome — findings that could guide future...
This study describes a new nanoparticle (Ce‑TA) that reduced inflammation and tissue injury in a common mouse model of colitis, suggesting a possible future therapeutic avenue for IBD driven by antioxidant and...
The study suggests quercetin can reduce inflammation and tissue damage markers in lab models of ulcerative colitis, pointing to ERK–MMP signaling as a possible mechanism. That could inform future preclinical research...
The study targets TLR2 activation by bacterial curli, a mechanism linked to inflammation in IBD and other immune conditions. Engineering curli to inhibit TLR2 could become a strategy to create probiotics that reduce...
Identifies IL-1RN and SERPINA1 as biomarkers linked to macrophage-driven inflammation in ulcerative colitis and shows TolDCs can reduce macrophage pro-inflammatory cytokine expression in lab experiments — findings that...
The study reports that kaempferol reduced inflammation, fibrosis, and barrier damage in mouse and cell models of colitis — mechanisms directly relevant to IBD progression and symptoms.
The study proposes a new immunomodulatory approach—phosphatidylserine liposomes—that reduced inflammation in mouse colitis models and altered monocyte and T-cell responses, which could point toward future therapies for...
If MSCs can limit ferroptosis via CBS, that points to a new biological pathway that might be targeted to reduce intestinal inflammation in Crohn's disease. This could guide future lab research and eventually early-phase...
The study evaluates whether microbial networks differ between groups (including sexes) in IBD and other diseases using a rigorously tested method; that matters because robust methods are needed before microbiome patterns...
The paper reframes Crohn’s disease and ulcerative colitis in terms of dominant T-helper immune pathways (TH1 vs TH22), which could steer research on targeted immunologic treatments and biomarkers.
The paper proposes molecular links between Crohn’s disease and Alzheimer’s disease through two genes implicated in inflammation and tissue remodeling. This could shape future research into shared gut–brain inflammatory...
Cure8 found this source from bioengineer.org, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article for the full details.
The paper identifies epothilone B as a repurposing candidate that may reduce neutrophil-driven inflammation and support epithelial healing in IBD models, a potential new strategy distinct from broad neutrophil...
The study links a traditional acupuncture-derived technique (ACE) to reduced colitis severity in rats and to modulation of the cGAS–STING immune pathway and macrophage marker profiles, suggesting a potential mechanistic...
The pipeline helps identify stem and progenitor epithelial cell states linked to inflammation in IBD. Knowing these cell states and biomarkers could guide research into disease mechanisms, tissue repair, and potential...
Mechanical forces in the gut may help drive fibroblast activation and early fibrosis in IBD; models that reproduce this could help researchers study and eventually target fibrotic pathways relevant to stricturing...
The study suggests a new macrophage-linked mechanism (NINJ2 → ZBP1 → PANoptosis) that may drive intestinal inflammation in IBD and could become a target for future therapies or biomarkers.
The paper links ileitis and changes in enterohepatic bile-acid composition to altered Th17 immune activity, suggesting bile-acid balance could influence inflammation in Crohn’s disease and might be a target for future...
The study links IRF5 to worse intestinal inflammation in UC and shows that reducing IRF5 activity lessens disease in a mouse model, suggesting IRF5 could be a future therapeutic target or biomarker.
The study presents a cell-free EV therapy that reduced inflammation in an experimental colitis model by reprogramming dendritic cells, which could inform future IBD treatments. It highlights a specific immunoregulatory...
The study presents a new inflammation-responsive oral delivery system designed to concentrate antioxidant and anti-inflammatory activity in the colon, which could—if translated safely to humans—offer a way to treat...
This method could let researchers study human intestinal tissue and its immune environment directly, potentially improving understanding of IBD mechanisms and how individual patients’ tissues respond to therapies.
This preclinical study links NOX1/4 and NLRP3 pathways to ferroptosis and iron metabolism in a mouse colitis model, highlighting potential mechanistic targets that could inform future precision therapies for ulcerative...
The study links high levels of the bile acid DCA to microbiome and metabolite changes that correlate with intestinal inflammation in mice, suggesting a possible pathway connecting high‑fat diets to colitis risk.
The review describes a novel preclinical approach—catalytic nanozymes—that aims to reduce oxidative stress and re-balance immune responses in ulcerative colitis, which could eventually lead to new treatments for patients...
A new fluorescent probe designed from bile acids may help image inflammation and has shown anti-inflammatory/antioxidant activity in cell studies relevant to ulcerative colitis, which could inform future diagnostic or...
Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Advances and Applications...
The findings identify a natural microbial metabolite (urolithin A) that appears to strengthen the intestinal barrier and aid tissue repair via a specific receptor and inflammasome pathway, suggesting new, more targeted...
The article highlights a natural gut-microbe product (urolithin A) that may help repair the intestinal lining by activating a protective molecular pathway.
The study identifies a macrophage-driven mechanism (IL-1β–linked ferroptosis-like lipid peroxidation) that may contribute to epithelial injury in Crohn’s disease, suggesting new biological targets that could eventually...
Improved detection of divergent RNA viruses in gut metatranscriptomes could help researchers better characterize the viral component of the microbiome in IBD and explore possible viral contributions to disease biology or...
A new small molecule that blocks the NLRP3 inflammasome via ProRS could point to future drug strategies for ulcerative colitis — a pathway involved in intestinal inflammation that matters to people with IBD. This is...
The paper connects a host microRNA (miR-29a) to gut microbiota bile-acid metabolism and an anti-inflammatory bile acid (LCA). If similar mechanisms apply in people, it could point to new biological targets or biomarkers...
The study introduces a colon-targeted EGCG delivery system that reduced inflammation and improved microbial and metabolic markers in a mouse model of UC, suggesting a potential new therapeutic approach worth further...
The study connects a genetic regulator (PACSIN2) and Rac1 signaling to cellular responses to mercaptopurine, a drug used in IBD, offering a possible explanation for why some patients experience thiopurine-related gut...
Phages shape the gut microbial community and may behave differently in inflamed guts. Understanding phage evolution in IBD could eventually inform microbiome-targeted therapies or explain disease-associated microbial...
The paper suggests that reduced folate transport can raise markers of inflammation-associated colon tumor initiation in mice, which is relevant because people with IBD are at higher risk for folate deficiency and colon...
Researchers link a bacterial metabolic pathway (pdu/pduB) in AIEC to intestinal inflammation and show that host vitamin B12 availability can reduce bacterial invasion and colitis in mice—suggesting a modifiable host...
If AIEC contribute to Crohn’s disease in some people, this study suggests bacterial metabolism linked to vitamin B12 can change how invasive and inflammatory those bacteria are. That points to the possibility of...
This study links an epigenetic mechanism in macrophages (H2A.Z deposition) to microbial metabolites (butyrate) and to genetic variants associated with IBD, which may help explain persistent inflammation and variable...
This preclinical study connects an herbal medicine to changes in gut microbiota, inflammation, and intestinal barrier function in a mouse model of ulcerative colitis — findings that could inform future research on new...
The study maps layer-specific gene programs in fibrostenotic Crohn's disease and pinpoints the submucosa as a hotspot for fibromuscular remodeling that underlies strictures and bowel obstruction risk.
The review connects Western diet-driven metabolic shifts in the gut, immune cells, and microbiota to ulcerative colitis mechanisms and highlights metabolism-targeting therapies as a potential future avenue for treatment.
