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Basic Science

Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.

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The SERPINB4 gene mutation identified in twin patients with Crohn's disease impaires the ... - Nature
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The SERPINB4 gene mutation identified in twin patients with Crohn's disease impaires the ... - Nature

This study links a specific SERPINB4 gene mutation to impaired intestinal epithelial cell function in twins with Crohn’s disease, which could help explain how rare genetic variants contribute to disease in some patients.

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