Evidence types
Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.
Page 4 of 15 · 708 articles
The work links a specific transcriptional regulator (GABPA) to STING-driven interferon and inflammatory responses and shows relevance to IBD and SLE patient samples, pointing to a potential new target for therapies aimed...
IBD patients often have depression and anxiety that current anti-TNF biologics do not adequately treat. An engineered probiotic that both neutralizes local TNFα and promotes GABA-producing microbes could address...
This study suggests an existing antimalarial drug, artemisinin, may reduce inflammation and improve gut barrier function in a mouse model of ulcerative colitis by targeting CD40 — a pathway relevant to immune-driven gut...
A colon-targeted delivery system could allow an anti-inflammatory plant extract (Myrica esculenta) to reach the colon with minimal systemic exposure, which may be relevant for developing localized treatments for...
The study identifies MrgprD on colonic macrophages as a driver of pro-inflammatory macrophage polarization and worse acute colitis in mice, highlighting a potential new pathway relevant to human IBD.
This study highlights macrophages — immune cells already suspected in IBD — and identifies MrgprD as a molecular driver in mouse colitis models, suggesting a new potential target that might one day lead to treatments...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Free Radical Biology...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Journal of Drug Delivery Science and...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Chemical Engineering...
The study identifies an A. muciniphila strain (WW001) that strengthened barrier function and reduced inflammation in lab and mouse models of colitis, pointing to a possible microbiome-based probiotic strategy for IBD...
Organoid models aim to reproduce human intestinal biology more closely than traditional cell lines or animal models, which could improve understanding of IBD mechanisms and help develop or personalize therapies.
The study shows functional differences in how Crohn’s versus healthy fecal microbiota ferment substrates, with CD cultures making less beneficial butyrate and more ethanol/amino acids. That could inform future...
The study links macrophage CD38-driven NAD depletion to intestinal inflammation and shows that restoring NAD or blocking CD38 reduced disease in experimental colitis—suggesting a new metabolic target for IBD therapies.
Viruses in the gut (including bacteriophages) could influence inflammation and the intestinal barrier in IBD, so understanding the virome may point to new research directions or therapies.
Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Radiation...
The article reports a new oral nanozyme that combines imaging and ROS-scavenging therapy aimed at IBD lesions—an early-stage approach that could one day enable targeted, noninvasive treatment and lesion tracking.
The study reports that Chlorella-derived polysaccharide AHP reduced inflammation, supported barrier repair, and changed gut microbiota in cell and mouse colitis models—suggesting a potential new bioactive candidate for...
The study links macrophage-driven CD38 activity to NAD+ depletion in colitis and shows that restoring NAD+ or blocking CD38 improved disease in experimental models — suggesting a new biological pathway that could lead to...
The paper links MKL1 to intestinal epithelial repair and shows it is elevated in IBD tissues, suggesting MKL1 helps restore the gut lining after injury — a key process in IBD recovery.
The study suggests a bacterial lysate and L-arginine can restore intestinal barrier function in cell and mouse models — a process that could be relevant to IBD because barrier dysfunction contributes to disease activity.
New computational tools that tie gene-expression to metabolic flux could help researchers identify metabolic pathways or biomarkers linked to ulcerative colitis, which might eventually inform research on disease...
Nanoencapsulated flavonoids are proposed as a way to improve delivery of biologically active dietary compounds to the inflamed gut in IBD; a rational design framework could accelerate translation from bench research to...
If creeping fat and mesenteric inflammation matter in your Crohn’s disease, this study suggests a new mechanism linking adipocyte autophagy to proinflammatory lipid mediators (oxylipins) and local immune activation —...
A company claims a novel quantum-based method has highlighted potential drug targets in diseases including Crohn’s disease, which could influence future drug discovery approaches. Investment by CDT Equity signals...
This preclinical study suggests a specific probiotic strain (Lp05) can increase regulatory T cells and reduce inflammation in a mouse colitis model, which could point to new microbiome-based approaches for IBD in the...
Metabolic interactions between epithelial and immune cells may help explain persistent inflammation and barrier problems in IBD and point to new therapeutic targets that could complement current immune-targeting drugs.
The review links changes in the microbiome and microbial polyamine production to immune cell imbalance that can drive both oral inflammation and IBD. Understanding this pathway could point to new research directions and...
m6A RNA methylation is a regulator of RNA function that may influence inflammation, immunity, and the intestinal microbiota — all central to IBD. Understanding these pathways could identify new biomarkers or drug targets...
This study describes a novel, non‑drug HA‑based nano‑assembly that targets inflammatory M1 macrophages and reshapes the colonic immune environment in mouse models of ulcerative colitis — a potential new therapeutic...
This study maps a shared transcriptional programme linking inflamed IBD tissue to colorectal cancer pathways, highlighting potential biomarker and prevention targets relevant to the inflammation-to-cancer transition.
Tools that predict which microbial or tumor peptides engage patient T cells could help researchers find antigens that trigger or drive autoimmune conditions (like some IBD cases) or that serve as targets for...
This study describes an engineered probiotic that senses a validated IBD inflammation biomarker (calprotectin) and produces IL‑2 locally, offering a potential new way to deliver anti‑inflammatory therapy on demand.
IBD patients have higher risk of colitis-associated colorectal cancer; this study suggests dietary choline might protect the intestinal barrier and reduce inflammation-driven tumor risk via a nutrient–transporter–Notch1...
Researchers are exploring ways to durably modulate macrophages in ulcerative colitis because persistent pro-inflammatory macrophages sustain tissue inflammation and impair healing.
Researchers are exploring natural compounds that might modulate immune pathways implicated in IBD. This study highlights ergothioneine as a bioactive mushroom compound that reduces pro-inflammatory signals in immune...
Finding reliable diagnostic biomarkers could help detect UC earlier and clarify immune mechanisms that drive disease; GPR97 is proposed here as such a marker and a possible immunomodulatory target, which may interest...
This study identifies a fibroblast-ILC3-pDC pathway that may help restrain gut inflammation and appears reduced in IBD tissue, highlighting a new non-immune cell mechanism relevant to disease biology.
The paper identifies a neutrophil-related immune pathway (KARAP → IDO1–kynurenine → AhR → IL-22) that contributes to mucosal inflammation in ulcerative colitis, suggesting a potential new target for research and drug...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Inflammation Research.
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and AI and data science. The original article is from Toxicological Research.
This identifies a metabolism-related epithelial gene (PCK1) linked to inflammation in UC and suggests acetyl‑L‑carnitine can partially reverse those changes in cell and mouse models—information that could guide future...
Links between circulating adaptive receptors, coordinated immune programs, and short-term treatment-response signals could eventually enable blood-based immune biomarkers or patient stratification tools in IBD research...
The study suggests stromal fibroblasts can drive pro-inflammatory neutrophil programs in ulcerative colitis and that targeting fibroblast-associated pathways may reduce neutrophil-driven inflammation—information that...
A colon-targeted, enzyme-activated imaging probe could help distinguish early versus late inflammatory stages in IBD and provide a noninvasive fecal fluorescence signal—potentially improving disease monitoring beyond...
The study identifies a food-industry by-product (crayfish shells) as a source of peptides that reduced inflammation and improved barrier and antioxidant markers in cell and mouse colitis models—research that could inform...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, AI and data science, and Research and clinical trials. The original article is from BMC Medical Research...
Identifies a fibroblast senescence signature and highlights ADAMTS2 as a candidate biomarker linked to inflammation and fibrosis in IBD, which could guide future diagnostic or therapeutic research relevant to Crohn’s...
Cure8 found this source from bioengineer.org, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. Open the original article for the...
