Evidence types
Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.
Page 6 of 15 · 709 articles
The paper identifies a molecular pathway (SERPINB5–MMP9–RLN2) by which the HDAC inhibitor trichostatin A reduced inflammation and protected the intestinal barrier in mouse and cell models of ulcerative colitis,...
The paper identifies a molecular pathway (miR-31-5p/SATB2) linked to UC progression to colitis-associated cancer and reports that resveratrol modulates this axis in mice, suggesting a potential preventive mechanism worth...
Disease-related changes in liver drug-metabolizing enzymes may alter how herbal formulas or medications are processed in people with UC, potentially affecting efficacy or safety. Understanding the mechanisms helps inform...
The study identifies HK2 inhibition as a potential mechanism to shift pro-inflammatory macrophages and reduce intestinal inflammation in preclinical models, which could guide future drug development for IBD.
People with IBD may hear about botanical treatments; this study provides preclinical data that Micromeria imbricata extracts showed beneficial effects in a mouse colitis model and identified compounds that dock to...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Materials today. Bio.
The work explores fundamental mechanisms by which inflammation may impair colonic epithelial identity and barrier integrity in ulcerative colitis — knowledge that could lead to new targets to improve mucosal healing.
The study reveals a new mechano-chemical mechanism regulating gut-homing integrin α4β7, which may help explain how lymphocytes home to inflamed intestines in IBD and points to a possible target for anti-adhesion...
Researchers identified COPZ1 as a shared ferroptosis-related hub gene in Crohn’s disease, ulcerative colitis, and periodontitis, which could point to a new molecular pathway linking gut and oral inflammation and a...
The work highlights a widespread tire-derived contaminant (6PPDQ) that may worsen colitis in a mouse model by disturbing key molecular pathways; this raises questions about whether environmental pollutants could...
The study links a common dietary flavonoid, epicatechin, to restoration of a protective ILC3 subset and mucosal repair in mouse colitis via a defined molecular pathway. This could point to new therapeutic targets for...
A single agent that both highlights inflamed colon tissue on MRI and delivers anti-inflammatory therapy could improve how ulcerative colitis is monitored and treated, reducing reliance on metal contrast agents.
This study identifies a specific gut microbe (Turicimonas muris) and an immune pathway link by which a high-fat diet reduced experimental colitis severity in mice, suggesting diet–microbiome interactions can strongly...
Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Inflammation.
The study identifies specific small molecules and polysaccharide features in Atractylodes macrocephala that correlated with reduced inflammation in a mouse model of ulcerative colitis, which could guide future...
Genetic variation in MYO9B has been linked to Crohn’s disease, ulcerative colitis, and celiac disease. This study suggests a plausible epithelial-cell mechanism — altered microvilli and RhoA signaling — that could help...
This study describes a programmable, inflammation-responsive engineered probiotic aimed at targeting IBD flares by sensing calprotectin and delivering antioxidant and epithelial-protective factors — a concept that could...
The paper describes a new nanodelivery method that improves targeted delivery of 5‑ASA in preclinical models, which could eventually address limitations of oral mesalazine formulations for colonic inflammation.
This study suggests airborne, soil-associated microbes can change the gut microbiome and reduce colitis severity in mice — a possible explanation for lower ulcerative colitis rates in rural areas. If similar effects...
This preclinical study suggests probiotic-derived extracellular vesicles may reduce intestinal inflammation and restore barrier function via PPARγ signaling and changes to the gut microbiome—an early step toward...
This study suggests a new preclinical approach to help the gut lining heal in ulcerative colitis by targeting macrophage metabolism (myeloid AMPK) rather than directly treating epithelial cells. That could matter for...
This paper describes a novel nanozyme that reduced oxidative stress and inflammation in preclinical models of colitis and enteropathic arthritis — a possible future therapeutic approach that targets ROS in inflamed gut...
The intestinal barrier changes in inflammation and can alter how oral nanocarriers interact with mucus and epithelium; understanding this is important for designing delivery systems that achieve local therapeutic benefit...
This study shows that sodium butyrate, a metabolite produced by gut bacteria, changed brain imaging measures and reduced inflammation in mice with experimental IBD, supporting the idea that gut-derived compounds can...
This review highlights a new, non-live microbiome-based therapy approach (probiotic-derived EVs) that could in future modulate gut immunity and barrier function without using live microbes. For people with IBD, such...
The study proposes a new redox-regulatory pathway (Grx1–STAT6) that helps M2 macrophages drive tissue repair and colitis recovery in preclinical models, pointing to a possible new therapeutic target to promote...
Identifies a molecule (CCL3) linked to more severe inflammation in IBD tissues, which could help researchers develop new biomarkers or treatments targeting immune-cell recruitment and polarization.
The study proposes a new oral nanoparticle that targets neutrophil-driven oxidative stress linked to mucosal barrier damage, a mechanism relevant to IBD pathology. If translatable, this approach could add a new modality...
Targeted oral delivery of melatonin could reduce inflammation and help repair the intestinal barrier in UC by acting on macrophages and epithelial cells. If translated to humans, this approach might offer a locally...
Better automated scoring tools for endoscopic images could reduce variability between human reviewers and help standardize assessments of ulcerative colitis severity used for treatment decisions and monitoring.
The study reports anti-inflammatory and antioxidant effects of a new andrographolide formulation in a macrophage model relevant to ulcerative colitis, highlighting a potential early-stage therapeutic lead that may...
Macrophage pyroptosis is increasingly implicated in driving intestinal inflammation and barrier damage in IBD, so understanding it could point to new treatment targets. Patients and clinicians may find this research...
Juvenile colorectal polyps in children show strong type 2 inflammatory and epithelial-remodeling programs that could explain links with allergic sensitization and suggest biomarkers and pathways relevant to mucosal...
The study identifies a β-glucan → IL-33 → active eosinophil pathway that reduced colitis in a mouse model, suggesting a novel immunomodulatory mechanism that could inform future IBD research.
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Biomedical Signal...
This mouse study connects fat malabsorption, increased gut permeability, microbiome shifts, and reduced oxalate transport to higher oxalate absorption and kidney injury—mechanisms relevant to enteric hyperoxaluria seen...
Researchers are exploring ways to improve cell therapies for IBD by making therapeutic cells produce anti-inflammatory molecules like IL-10. If scalable and safe, non-viral engineering of MSCs could lead to...
Piezo channels appear central to how mechanical signals influence the gut barrier, immunity, and secretion — processes that can affect inflammation and symptoms in IBD, IBS, and colon cancer. Understanding them could...
Researchers aim to build and study tiny gut phages (Microviridae) that are largely known only from DNA sequences. Learning how these phages shape microbial communities could help explain virome-linked changes seen in...
This project aims to understand how gut-adapted eosinophils support immune homeostasis or drive pathology in conditions that include IBD and eosinophilic GI disorders, with the goal of enabling more precise...
Barrier dysfunction is central to IBD pathogenesis; a compound that restores tight junctions and reduces permeability in preclinical models could eventually lead to new therapies that protect the gut lining and reduce...
A new single-cell analysis tool may help researchers and clinicians studying IBD (here shown for ulcerative colitis) to detect and interpret changes in cell–cell signaling that accompany disease or treatment response.
This study reports a non-invasive fluorescence probe that detects a reactive nitrogen species (peroxynitrite) linked to intestinal inflammation and shows signal changes in cells, animal models, and mouse feces — a...
A naturally occurring pigment (C3G) improved inflammation and barrier markers in a mouse colitis model, which could be of interest to people exploring nutrition-related ways to support gut health.
This study describes a new microbiome-engineering approach that reduced inflammation in mouse colitis models by sequestering cysteine and altering T cell behavior. If followed up, it could point to novel future therapies...
PFAS exposure is widespread; if PFNA worsens intestinal inflammation through a defined immune pathway, it could help explain environmental contributions to IBD flares and point to new research targets for mitigation.
This study provides preclinical evidence that an anthocyanin (cyanidin-3-O-glucoside) can reduce inflammation and preserve the intestinal barrier in a mouse colitis model, highlighting a possible dietary mechanism...
Macrophage behavior and metabolic reprogramming help drive inflammation or repair in ulcerative colitis, so understanding these processes could point to new therapies. The review links lab methods and ongoing clinical...
