Evidence types
Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.
Page 7 of 15 · 709 articles
This study describes a novel colon-targeted microgel delivery system carrying an anti-inflammatory natural compound that, in a mouse model, reduced colitis signs and altered gut bacteria — a potential new strategy for...
This atlas maps when and where regenerative gene programs turn on in the intestine and highlights molecular features (like interferon responses and hypertranscription) that overlap with human Crohn’s disease, so it could...
Researchers can use these human tissue slice cultures to study inflammation and test drugs on a patient’s own biopsy tissue, which could eventually help explain treatment response or resistance in IBD and related...
The study links a common dietary fiber (green banana resistant starch) to microbiota changes and production of propionate that protect the colonic barrier and reduce inflammation in a mouse model of ulcerative colitis.
This study proposes specific plant compounds and molecular pathways that could be relevant to ulcerative colitis, which may guide future lab research and drug-discovery efforts. For people with UC, it points to...
The study suggests molecular targets and pathways through which a traditional herbal formula might influence UC biology, offering testable hypotheses for future lab and clinical research.
Researchers are exploring ways to deliver drugs selectively to inflamed gut tissue in IBD to boost local effectiveness and reduce systemic side effects. Progress in smart nanoparticles and hydrogels could eventually...
Researchers identified a plant-derived molecule (oxypalmatine) that reduced inflammation in a mouse colitis model by blocking pro-inflammatory macrophage activity through the RAB8A–STAT1 pathway. This suggests a...
The study suggests that timing of eating (time-restricted feeding) may influence intestinal inflammation and gut microbiota in ways that could be relevant to IBD. If confirmed in humans, meal timing could be a low-cost...
A plant polysaccharide (PVP) reduced inflammation and preserved intestinal barrier proteins in a mouse model of ulcerative colitis, apparently by increasing a specific gut bacterium. This points to a microbiome-related...
Researchers are working to link specific gut microbes and their metabolites to host molecular changes in ulcerative colitis. This study maps candidate microbe–metabolite–host gene connections that could point to new...
Non-invasive, portable tests that can track inflammation more frequently could help patients and clinicians monitor disease activity between clinic visits and guide treatment decisions without repeated invasive...
The study identifies osteopontin as a stromal-secreted protein elevated in IBD-derived colonic fibroblasts and shows it can restrain epithelial maturation in human colonic organoids, a mechanistic insight that could be...
The study highlights a bacterial gene that helps adherent-invasive E. coli (AIEC) colonize the gut — a mechanism that has been linked to Crohn's disease. Understanding how AIEC colonizes could guide future research into...
People with IBD are at higher risk for colorectal cancer; identifying stromal genes that track inflammation-driven EMT could help researchers find biomarkers or targets that explain how chronic inflammation promotes...
Researchers identified licochalcone B as a compound that reduced inflammation and repaired gut barrier in a mouse colitis model by affecting PI3K/AKT signaling and purine metabolism. For people following IBD research,...
The work links a PD risk gene (LRRK2 G2019S) to increased intestinal NET formation and enteric α-synuclein in mouse colitis, suggesting a neutrophil-mediated inflammatory route by which gut inflammation and microbiota...
AIEC bacteria have been linked to Crohn’s disease; this study identifies a bacterial gene (rfaG) that helps AIEC express adhesins and colonize the gut in experimental models, which could point to future research paths...
The study links a common environmental chemical (BPA) to worse epithelial injury and inflammation in colitis models, highlighting a potential environmental contributor to IBD-relevant epithelial dysfunction and...
Researchers used machine learning and molecular docking plus small animal tests to link a common plasticizer (DEP) with molecular changes seen in pediatric Crohn’s disease. This could point to environmental exposures...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and AI and data science. The original article is from International journal of surgery...
Identifies mast-cell–derived IL-13 as a likely contributor to intestinal fibrosis in Crohn disease, a complication not reliably prevented by current anti-inflammatory treatments. The finding points to a specific immune...
The study suggests that air pollutant NO2 may promote a perforin-producing CD8+ T cell response linked to colonic inflammation in UC and highlights CDC25B as a potential mechanistic link—information that could guide...
The review highlights metabolic pathways (mTOR–glycolysis) that drive inflammation and barrier dysfunction in ulcerative colitis, which could point to new kinds of targeted therapies beyond current immunosuppressive...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Drug...
The study expands the map of gut archaea and identifies archaeal species associated with IBD/UC, suggesting new microbial biomarkers and potential microbe–microbe interactions that might influence inflammation.
The study suggests a steroid‑sparing combination (low‑dose atorvastatin plus reduced prednisolone) may produce stronger anti‑inflammatory and antioxidant effects than either drug alone in an animal model of ulcerative...
This preclinical study suggests that a specific gut microbe (Bacteroides acidifaciens) and the bile acid UDCA can reduce inflammation in a mouse colitis model by improving barrier function and dampening NLRP3-driven...
People with chronic colitis/IBD have higher rates of cardiovascular disease. This mouse study identifies a gut microbiota → immune cell → cardiac pathway (TLR4–GBP1) that might explain that link and point to future...
Identifying baseline cellular states that predict disease course or response to anti‑TNF could help researchers develop predictive biomarkers and new therapeutic strategies for pediatric Crohn’s disease.
The study outlines a strategy to target corticosteroids to inflamed intestinal tissue by exploiting PLA2 overexpression, which could reduce systemic steroid side effects if the approach translates to biological models...
The review presents an emerging nanotechnology (TCM-derived carbon-dot nanozymes) that could offer new multitarget anti-inflammatory and antioxidant approaches for IBD, addressing limitations of current therapies and...
Researchers identified potential anti‑inflammatory mechanisms in a multi‑component herbal formula relevant to IBD pathways (NF‑κB, IL‑17) and showed in vitro reduction of pro‑inflammatory cytokines, which could guide...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Pharmacological...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Sensors and Actuators...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Fitoterapia.
This mouse study suggests that acute colitis can alter liver immune responses—reducing CD8 T cells and shifting macrophages toward an anti-inflammatory M2 state—which may affect autoimmune cholangitis. That connection...
People with UC may care because the study identifies a compound and a signaling pathway that lowered inflammation and tissue injury in a commonly used mouse model of colitis, suggesting potential future therapeutic...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...
The study maps cell-level programs in ileum and colon that associate with failure to respond to biologic therapies, suggesting specific cellular markers and niches that could help explain treatment resistance and guide...
The study suggests a common environmental pollutant could worsen intestinal inflammation in experimental colitis and identifies molecular pathways that might mediate that effect, which could be relevant to understanding...
The study provides a more rigorous, leakage-free machine-learning analysis of a major IBD microbiome cohort and proposes reproducible microbial and metabolic pathway candidates that could eventually help IBD diagnosis or...
Researchers are exploring plant-derived polyphenols as potential anti-inflammatory agents for IBD. This preclinical study suggests a Tsaoko Fructus extract reduced colitis in mice, altered the gut microbiome toward...
The study reports a newly discovered class of marine-derived meroterpenoids and identifies a lead compound that reduced inflammatory markers and improved colitis in mice, which could eventually inform new drug...
The study explores how gut inflammation might influence liver autoimmune disease, which is relevant because people with IBD can have associated autoimmune cholangitis conditions. Understanding immune and metabolic links...
The study identifies a new compound that reduced colitis severity in mice by acting on macrophage NF-κB signaling, lowering MMP7, improving epithelial barrier markers, and altering the gut microbiome — mechanisms...
