Evidence types
Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.
Page 8 of 15 · 709 articles
The study suggests a plant-derived extract can reduce inflammation and help restore the intestinal epithelial barrier in laboratory models of ulcerative colitis, which is directly relevant to research into new IBD...
This paper identifies a herbal formula that improved inflammation and epithelial barrier repair in a mouse colitis model and highlights specific molecular pathways (CAV1/FAK/paxillin and metabolite pathways) that might...
Researchers identified molecular features of a proposed “ferro‑aging” state in UC and nominated CHST15 and MSN as biomarkers, which could help understand disease biology and point to new experimental targets for therapy...
This study reports a new engineered platform that can catalytically degrade TNF‑α, the same inflammatory cytokine targeted by several IBD therapies. If translated to humans, it could offer longer‑lasting mucosal...
This mouse study suggests a blueberry-derived anthocyanin plus pectin complex can alter gut microbes and metabolites linked to inflammation, pointing to a dietary approach that might influence ulcerative colitis biology.
IBD can cause cognitive and neurological symptoms. This preclinical study suggests a flavonoid-rich Chrysanthemum extract reduced colitis and related cognitive deficits in mice by changing the gut microbiota and...
The study identifies a plant-derived compound (curcumol) that reduced inflammation, mucosal injury, and some microbiome/metabolome disturbances in a mouse model of ulcerative colitis and links these effects to...
Researchers are exploring new anti-inflammatory molecules for ulcerative colitis. Mechanistic data showing inhibition of macrophage M1 polarization, MAPK signaling, and antioxidant activity may help prioritize VpG for...
Butyrate supports intestinal health and is often low in IBD. A single oral compound that reliably restores luminal butyrate could — if proven safe and effective in humans — offer a new way to treat ulcerative colitis or...
Researchers working on IBD molecular mechanisms or biomarker discovery may find this AI-driven approach useful because it can detect temporal gene-expression patterns and suggest pathways linked to treatment response...
People with UC or IBD may be interested because the study identifies plant-derived compounds that reduce inflammation in lab models of ulcerative colitis and points to molecular pathways relevant to IBD.
Environmental cadmium exposure may alter the gut microbiome’s metabolites (oleic acid) and worsen colitis in mice via FFAR4-linked inflammatory pathways. If similar mechanisms operate in people, this could point to new...
PSC frequently occurs with IBD and has unclear origins; understanding a shared glandular mechanism could help explain the link and point to new research targets relevant to both liver and colon disease.
This study identifies conserved, gut-enriched genes (colonization factors) and shows their repertoires are remodeled in IBD, highlighting functional microbiome changes that could inform future biomarkers or...
This research suggests a new way the gut could “remember” prior injury: lasting changes in the tissue scaffold (ECM) that may push stem cells toward pro‑inflammatory behavior and help explain recurring IBD flares.
The study points to CD226 (DNAM-1) being linked to inflammatory and interferon-driven programs in specific intestinal immune cells in Crohn's disease, which may be relevant to understanding disease mechanisms or...
People with IBD might be interested because the study explores a new natural-product intervention that appears to reduce colitis severity in an animal model by activating the Nrf2 antioxidant pathway — a pathway already...
The study identifies ABTB1 as a regulator that limits STAT3-driven Th17 differentiation and reduces severity in a mouse colitis model, suggesting a new molecular pathway relevant to IBD inflammation and a potential...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Visualized...
Fistulizing Crohn’s disease is a major complication where durable structural repair is hard to achieve. Regenerative cell-sheet approaches aim to rebuild tissue architecture rather than only suppress inflammation, which...
The paper suggests gut bacteria make an anti-inflammatory metabolite (NOP) that accumulates in IBD and reduces inflammatory responses in cells and multiple mouse colitis models, pointing to a potential microbiome-derived...
Researchers present a small platelet-related gene signature (TRIM22, TIMP1, RAC2) that may help understand UC biology and point toward blood-based biomarkers. If validated further, such markers might aid noninvasive...
The study describes a new molecular axis (Uhrf1 → PKM2 ubiquitination) that reduced inflammation and pyroptosis in IBD models and identifies a compound (EPT) that promotes this interaction — a potential early-stage...
Fucosylation appears to influence intestinal barrier function, host–microbiota interactions, and immune responses — processes central to IBD pathogenesis. If validated, fucosylation-related biomarkers or therapies could...
This study suggests a new, compact DNA-methylation biomarker that identifies accelerated aging in the colon linked to chronic inflammation (IBD) and pre-cancerous conditions. Such biomarkers could eventually help...
The study suggests a traditional Chinese medicine formula can reduce disease signs in a mouse model of chronic relapsing ulcerative colitis and that its effects are mediated by changes in the gut microbiota and microbial...
The study reports an experimental coating that both protects a probiotic and provides antioxidant, anti-inflammatory effects in a mouse colitis model—an approach that, if validated in humans, could improve probiotic...
The study targets macrophage mitochondrial dysfunction, a mechanism linked to inflammation in ulcerative colitis, and demonstrates a nanodelivery approach that reduced colitis in mice—an approach that could inspire new...
The study suggests a natural seaweed-derived polysaccharide could modify gut bacteria and immune signaling in ways that reduced experimental colitis, which may interest people looking for microbiota-targeted dietary...
This method helps translate complex paired microbiome and metabolome data into coherent functional modules; that could clarify microbial metabolic alterations in IBD or IBS and guide future biomarker or mechanistic...
This work suggests that non-immune stromal cells can hold an epigenetic ‘memory’ that keeps intestinal tissue in a disease-promoting state, which may help explain relapse or incomplete responses to immune-focused...
The study points to specific immune pathways (especially Th17 differentiation) and molecular targets that might explain DSP’s anti-inflammatory effects in ulcerative colitis, which could guide further preclinical and...
The study links a polyphenol-rich diet to a specific microbiome change and a microbial metabolite (4-HPAA) that reduced inflammation in mouse models — offering a possible mechanism by which diet could influence Crohn's...
Researchers describe a natural peptide that binds IL‑17RA and reduced disease measures in mouse colitis models — a potential new mechanism for reducing gut inflammation and restoring the epithelial barrier that could...
This study describes a new oral peptide hydrogel that, in mouse models, appears to reduce colitis severity by acting on both immune signaling (TLR4) and the gut microbiome. For people with UC, treatments that target both...
The study identifies a molecular link between epithelial mitochondrial oxidative stress and NLRP3-driven inflammation in ulcerative colitis models, suggesting a possible new target for research into disease mechanisms...
Treg/Th17 balance is a central immune mechanism implicated in IBD pathogenesis; understanding how microbes, metabolites, and tissue context control that balance could inform new biomarkers and targeted therapies.
The study links TXNIP/NLRP3 inflammatory signaling to disease features in an animal UC model and tests engeletin and rosuvastatin as interventions that lowered inflammatory markers—information relevant to researchers...
Colon-targeted delivery systems aim to concentrate drugs in the colon, which could improve effectiveness and reduce systemic side effects for IBD and colorectal cancer treatments. Understanding these approaches helps...
The study links activation of the cGAS–STING immune-sensing pathway to NF-κB–driven inflammation and tumor formation in UC models, which could help explain mechanisms behind colitis-associated colorectal cancer risk.
The study identifies a gut bacterial metabolite that appears to reduce intestinal inflammation through SIRT1 stabilization and macrophage metabolic reprogramming — a potential new biological pathway relevant to Crohn’s...
This study reports a new herbal hydrogel designed to repair the intestinal barrier, shift gut microbes, and modulate immune signals (IL-22/IL-34) in preclinical models of ulcerative colitis—ideas that could inform future...
The paper identifies a potential microbiome–metabolite–PKC pathway by which an herbal formula reduced colonic injury in a rat model of UC; this could point to new targets for research into mucosal repair and...
People with ulcerative colitis may be interested because the study describes a natural compound that reduced inflammation and disease signs in a mouse model and acted through the gut microbiota and immune pathways —...
The study identifies miR-23b-3p as elevated in UC and CD and linked to disease severity, and shows in cell models that lowering miR-23b-3p can improve epithelial barrier function via Erbin. If confirmed, this miRNA could...
The study links NAD+ precursor (NMN) supplementation to changes in TGF-β–associated gene programs, intestinal immune signatures, and the gut microbiome in mouse colitis models — pathways relevant to fibrosis and...
The paper links common tire-derived pollutants to intestinal injury and pathways also implicated in Crohn’s disease and ulcerative colitis, suggesting environmental chemicals could influence gut inflammation. If...
The study describes a mechanism by which Huaier granules reduced colitis-related inflammation in mice and cell models by targeting macrophage cGAS–STING signaling and altering the gut microbiome—information that could...
