Condition

Inflammatory bowel disease

Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.

Page 14 of 88 · 4177 articles

Multi‐omics and machine learning identify neutrophil annexin A3 as a therapeutic target of ginsenoside Rb1 for comorbidity of ischaemic stroke and ulcerative colitis
British Journal of Pharmacology

Multi‐omics and machine learning identify neutrophil annexin A3 as a therapeutic target of ginsenoside Rb1 for comorbidity of ischaemic stroke and ulcerative colitis

This study links a neutrophil protein (ANXA3) to both ulcerative colitis and ischaemic stroke and suggests a compound (ginsenoside Rb1) can bind ANXA3 and reduce neutrophil hyperactivation in lab tests — a potential...

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Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis
Cells

Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis

The work highlights molecular differences between PSC-UC and typical UC that could help explain higher colorectal cancer risk in PSC-UC and suggests candidate miRNA biomarkers (eg, miR-155) for further study.

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Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation
Frontiers in Immunology

Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation

Engineered extracellular vesicles are an emerging, targeted therapy approach that could someday improve immune control, mucosal healing, and drug delivery in IBD and reduce colitis-associated cancer risk. The review...

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Perspectives of gastroenterologists on an educational curriculum to promote self-management in young adults with inflammatory bowel disease
Journal of the Canadian Association of Gastroenterology

Perspectives of gastroenterologists on an educational curriculum to promote self-management in young adults with inflammatory bowel disease

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association of...

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The sustainability and environmental impact of virtual care for inflammatory bowel disease: a population-based retrospective cohort study
Journal of the Canadian Association of Gastroenterology

The sustainability and environmental impact of virtual care for inflammatory bowel disease: a population-based retrospective cohort study

Based on the title and source metadata, this appears to be an observational study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association...

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Efficacy of Fermented Brown Rice by Aspergillus oryzae (FBRA) in Ulcerative Colitis: A Double‐Blind Randomized Trial
JGH open : an open access journal of gastroenterology and hepatology

Efficacy of Fermented Brown Rice by Aspergillus oryzae (FBRA) in Ulcerative Colitis: A Double‐Blind Randomized Trial

Based on the title and source metadata, this appears to be a clinical trial phase 3 related to Ulcerative colitis, Inflammatory bowel disease, and Diet and lifestyle. The original article is from JGH open : an open...

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Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies
Immunity, inflammation and disease

Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Crohn's disease, Inflammatory bowel disease, and Microbiome. The original article is from Immunity, inflammation...

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Irritable bowel syndrome-like symptoms are associated with increased healthcare utilization in patients with inflammatory bowel disease
Frontiers in gastroenterology (Lausanne, Switzerland)

Irritable bowel syndrome-like symptoms are associated with increased healthcare utilization in patients with inflammatory bowel disease

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Irritable bowel syndrome, and Symptoms and flares. The original article is from Frontiers in...

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Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis
Advanced Science

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

The paper suggests that changes in how microbes interact (community plasticity and network structure) may underlie microbiome differences seen in ulcerative colitis and could point toward ecology-informed biomarkers or...

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Carboxymethyl chitosan-sodium alginate/carboxymethyl cellulose pH-responsive efficient drug-loaded gel for the treatment of inflammatory bowel disease.
International journal of biological macromolecules

Carboxymethyl chitosan-sodium alginate/carboxymethyl cellulose pH-responsive efficient drug-loaded gel for the treatment of inflammatory bowel disease.

Researchers are exploring ways to deliver steroids like budesonide more precisely to the intestine while avoiding stomach leakage and sudden drug release. If translated to humans, such a formulation could improve local...

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Nailfold capillary density in inflammatory bowel disease: Associations with disease activity and systemic inflammation.
Microvascular research

Nailfold capillary density in inflammatory bowel disease: Associations with disease activity and systemic inflammation.

Patients and clinicians are often looking for objective, noninvasive ways to monitor IBD activity. This study suggests a simple nailfold capillary measure may reflect disease activity and add information to CRP, which...

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Menispermum dauricum rhizome alkaloids ameliorate colitis by inhibiting mitochondrial DNA synthesis via the JAK2-STAT4-AK4 pathway.
Journal of ethnopharmacology

Menispermum dauricum rhizome alkaloids ameliorate colitis by inhibiting mitochondrial DNA synthesis via the JAK2-STAT4-AK4 pathway.

This study identifies a new molecular pathway (JAK2–STAT4–AK4–mtDNA) linked to inflammatory macrophage activity in experimental colitis and presents a plant-derived alkaloid mixture (TAMR) that modulates that pathway....

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EFFICACY AND SAFETY OF ADVANCED THERAPIES AS INDUCTION THERAPY FOR ULCERATIVE COLITIS: AN UPDATED SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

EFFICACY AND SAFETY OF ADVANCED THERAPIES AS INDUCTION THERAPY FOR ULCERATIVE COLITIS: AN UPDATED SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.

Patients and clinicians choosing induction therapy for moderate‑to‑severe ulcerative colitis may find comparative efficacy and safety data useful, especially when head‑to‑head trials are limited. The review highlights...

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Multi-cohort meta-analysis, single-cell and Mendelian randomization analyses with experimental validation identify RHBDF2 as a shared mediator of ulcerative colitis and blood–brain barrier disruption
Frontiers in Synaptic Neuroscience

Multi-cohort meta-analysis, single-cell and Mendelian randomization analyses with experimental validation identify RHBDF2 as a shared mediator of ulcerative colitis and blood–brain barrier disruption

The paper suggests a molecular link (RHBDF2–ADAM17–TNFα) between ulcerative colitis and blood–brain barrier disruption, which could explain some neurological comorbidities of UC and identify targets for future therapies.

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Biologic and small-molecule therapies for inflammatory bowel disease: mechanisms, comparative evidence and the emerging pipeline
Frontiers in Pharmacology

Biologic and small-molecule therapies for inflammatory bowel disease: mechanisms, comparative evidence and the emerging pipeline

This review summarises the rapidly changing drug landscape for Crohn’s disease and ulcerative colitis, including newly approved biologics and small molecules and several emerging therapies that may affect future...

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Barrier-reinforcing hyaluronic acid-bilirubin nanodelivery of methylprednisolone for synergistic modulation of the intestinal barrier, immune system, and gut microbiome in colitis.
Journal of controlled release : official journal of the Controlled Release Society

Barrier-reinforcing hyaluronic acid-bilirubin nanodelivery of methylprednisolone for synergistic modulation of the intestinal barrier, immune system, and gut microbiome in colitis.

Researchers are exploring ways to deliver steroids to the inflamed gut while lowering systemic side effects; a nanoparticle carrier that protects the epithelium and concentrates drug in the colon could, if translated,...

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Spleen-targeted ultrasound restores gut-brain homeostasis in colitis via vagal neuroimmune modulation.
Brain, behavior, and immunity

Spleen-targeted ultrasound restores gut-brain homeostasis in colitis via vagal neuroimmune modulation.

The study suggests a noninvasive spleen-targeted ultrasound approach can reduce gut and brain inflammation and improve behavior in a mouse colitis model, mediated by vagal signaling—pointing to a possible new avenue for...

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Computed tomography enterography-defined transmural healing is associated with lower hospitalization risk in patients with Crohn's disease.
Intestinal research

Computed tomography enterography-defined transmural healing is associated with lower hospitalization risk in patients with Crohn's disease.

Transmural healing on CT enterography was associated with fewer hospitalizations over long follow-up, which could matter for long-term disease management and monitoring strategies in Crohn’s disease.

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Trends and safety of small bowel endoscopy in Crohn's disease in Japan: a large-scale claims database analysis.
Intestinal research

Trends and safety of small bowel endoscopy in Crohn's disease in Japan: a large-scale claims database analysis.

Small-bowel capsule and balloon-assisted endoscopy are increasingly used for Crohn’s disease; this large real-world study suggests adverse events after SBCE are uncommon and may be less frequent when a patency capsule is...

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Disease characteristics, outcomes, and poor prognostic factors of perianal fistula in Korean patients with Crohn's disease: a multicenter, retrospective observational study.
Intestinal research

Disease characteristics, outcomes, and poor prognostic factors of perianal fistula in Korean patients with Crohn's disease: a multicenter, retrospective observational study.

Perianal fistulas are common and burdensome in Crohn’s disease; this large multicenter Korean study quantifies high rates of complex fistulas, frequent recurrence, and suggests biologic therapy is associated with fewer...

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Comments on “Upadacitinib and vedolizumab combination therapy for the management of refractory ulcerative colitis and Crohn’s disease”

Cure8 could only read part of this source from Intestinal Research, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease.

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+ Metabolic reprogramming of pathogenic CD4T helper cells attenuates inflammatory bowel disease in mice.
Science signaling

+ Metabolic reprogramming of pathogenic CD4T helper cells attenuates inflammatory bowel disease in mice.

The study links T cell metabolism and epigenetics to inflammation in IBD, highlighting GSK3β as a possible drug target. That could guide future therapies aimed at dampening pathogenic T cells in Crohn’s disease.

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ACSS2-dependent histone lactylation amplifies ferroptotic injury via a metabolic feedback loop in ulcerative colitis
Genome Medicine

ACSS2-dependent histone lactylation amplifies ferroptotic injury via a metabolic feedback loop in ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Genome Medicine.

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SYSTEMATIC REVIEW AND BRAZILIAN EXPERT CONSENSUS ON THE USE OF BIOSIMILARS IN INFLAMMATORY BOWEL DISEASE: BRAZILIAN ORGANIZATION FOR CROHN’S AND COLITIS Revisão Sistemática e Consenso Brasileiro de Especialistas sobre o Uso de Biossimilares na Doença Inflamatória Intestinal: Organização Brasileira de Doença de Crohn e Colite (GEDIIB)
Arquivos de gastroenterologia

SYSTEMATIC REVIEW AND BRAZILIAN EXPERT CONSENSUS ON THE USE OF BIOSIMILARS IN INFLAMMATORY BOWEL DISEASE: BRAZILIAN ORGANIZATION FOR CROHN’S AND COLITIS Revisão Sistemática e Consenso Brasileiro de Especialistas sobre o Uso de Biossimilares na Doença Inflamatória Intestinal: Organização Brasileira de Doença de Crohn e Colite (GEDIIB)

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease, Crohn's disease, and Biosimilars. The original article is from Arquivos de...

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The Bidirectional Relationship Between Cognitive Function and Active Inflammatory Bowel Disease
The American journal of gastroenterology

The Bidirectional Relationship Between Cognitive Function and Active Inflammatory Bowel Disease

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from The American journal of gastroenterology.

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Mechanistic insights into sitagliptin’s action in rat inflammatory bowel disease: involvement of the NO-cGMP-KATP pathway
Research in pharmaceutical sciences

Mechanistic insights into sitagliptin’s action in rat inflammatory bowel disease: involvement of the NO-cGMP-KATP pathway

Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Research in pharmaceutical sciences.

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Harnessing Paeonia lactiflora-derived antioxidant carbon dots as oral nanomedicine for ulcerative colitis therapy by restoring intestinal mucosal barrier and microbiota homeostasis
Nano Today

Harnessing Paeonia lactiflora-derived antioxidant carbon dots as oral nanomedicine for ulcerative colitis therapy by restoring intestinal mucosal barrier and microbiota homeostasis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Nano Today.

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Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis
ClinicalTrials.gov

Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis

A pediatric trial of budesonide rectal foam could provide evidence about a locally acting steroid option for children with distal ulcerative colitis. Trial results may affect treatment choices for pediatric distal...

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Acetylation–ubiquitination crosstalk in NLRP3–gasdermin pyroptosis: a substrate-state framework with relevance to ulcerative colitis
Frontiers in Immunology

Acetylation–ubiquitination crosstalk in NLRP3–gasdermin pyroptosis: a substrate-state framework with relevance to ulcerative colitis

The molecular interaction between acetylation and ubiquitination on NLRP3 and GSDMD could help explain mechanisms of inflammatory cell death relevant to UC and point to new biomarker or therapeutic targets, but direct...

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A protein-prioritised, colocalisation-informed genetic framework for safety hypothesis generation across inflammatory bowel disease therapeutic pathways
Journal of Translational Medicine

A protein-prioritised, colocalisation-informed genetic framework for safety hypothesis generation across inflammatory bowel disease therapeutic pathways

Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of Translational Medicine.

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Interpreting Transperineal Ultrasound Features of Perianal Fistula Activity in Pediatric Crohn's Disease.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Interpreting Transperineal Ultrasound Features of Perianal Fistula Activity in Pediatric Crohn's Disease.

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Fistula. The original article is from Journal of ultrasound in medicine : official...

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The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence
Nutrients

The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence

Berries are a familiar, dietary source of anti-inflammatory bioactive compounds that might help reduce intestinal inflammation and improve biomarkers relevant to IBD. Patients often seek safe, complementary strategies...

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