Condition
Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.
Page 14 of 48 · 2295 articles
People with moderate-to-severe Crohn's disease or ulcerative colitis and their clinicians may want to know how long patients stay on guselkumab in real-world care, since persistence reflects tolerability, benefit, and...
Early-phase trials test safety and tolerability of new mechanisms; this study evaluates an anti–IL-18 antibody (aletekitug) which could represent a different therapeutic approach for people with moderate-to-severe UC if...
This study evaluated whether blood levels of LRG track endoscopic and clinical disease activity in people with suspected UC or Crohn’s disease, which could point to a noninvasive inflammation biomarker.
Diet can change gut microbes and their metabolites; this trial tests whether a high-protein, high-fiber diet can lower a microbe-derived compound (H2S) thought to be relevant in UC. If effective, diet-based approaches...
Real‑world studies of ustekinumab help patients and clinicians understand how the drug performs outside clinical trials, including effectiveness for steroid‑free remission and use across different UK care settings.
Surgical approach to creating an IPAA (j-pouch) affects timing and number of operations and recovery; trends toward more staged procedures may reflect increasing disease severity and preoperative treatment patterns that...
Dual-energy CT quantification of creeping fat could offer a measurable imaging biomarker that reflects transmural inflammation and fibrosis in Crohn’s disease, potentially improving monitoring beyond mucosal healing.
The study examines real-world activity and sedentary patterns in people with Crohn’s disease compared with matched controls and highlights sitting-time differences that could be modified without formal exercise programs.
Some people with IBD who have respiratory symptoms may have lasting problems with lung gas exchange even when their bowel disease is inactive. Knowing this can prompt clinicians to check lung function rather than...
The work narrows down which genes are likely influenced by Crohn’s disease–associated regulatory DNA in a specific gut immune cell type, helping researchers prioritize targets and understand disease mechanisms.
IBD is linked with mood and cognitive symptoms via systemic and gut‑brain inflammation, so preclinical findings that a cashew kernel extract reduced inflammation and behavioral changes could point to new research...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
Depression is common in people with ulcerative colitis and affects quality of life and disease outcomes. Knowing research trends helps patients and clinicians see where evidence and care approaches are focused,...
Finding shared genes (CLDN8, ABCA12) suggests common inflammatory mechanisms between ulcerative colitis and psoriasis, which could inform future biomarkers or therapies relevant to patients with either or both...
The study shows a probiotic strain reduced inflammation and improved gut barrier and microbiome/metabolite profiles in a mouse colitis model, indicating a possible new avenue for UC therapies worth further research.
Cure8 found this source from Gastroenterology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article for the full details.
This study helps distinguish patterns of colorectal dysplasia seen in people without IBD from those seen in IBD, which may affect how pathologists and clinicians interpret biopsy findings and consider cancer risk and...
This study identifies a plant-derived compound that reduced inflammation and promoted intestinal healing in mouse models by modulating the Wnt/β-catenin pathway and ILC3-driven IL-22 production—pathways relevant to...
XOR is linked to oxidative stress, inflammation, drug (thiopurine) metabolism, microbiome interactions, and inflammation-associated colorectal cancer — all processes relevant to IBD pathogenesis and complications....
People with IBD already face higher cardiovascular risk; drugs used to treat IBD (anti-TNF and JAK inhibitors) may differently affect small-vessel endothelial function, a possible contributor to heart and vascular...
The study links patient-specific non-coding genetic variation to epithelial regulatory networks and to differences in disease severity and response in a large UC trial, suggesting genetics could help explain why some...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and CRP. The original article is from Alimentary Pharmacology & Therapeutics.
People with Crohn’s or ulcerative colitis can rarely develop lung problems related to their disease or its treatments, and this review collates what is known about clinical features and therapies.
This review describes a novel, targeted microbiome approach (phage therapy) aimed at bacteria linked to Crohn’s disease. If effective and proven safe in trials, phage therapy could offer a more precise way to reduce...
A person with Crohn disease on multiple immunosuppressive drugs was reported to have tracheobronchial wall thickening, an extraintestinal finding that could reflect infection or inflammation. This may be relevant for...
This study compares two commonly used anti‑TNF biologics in children with Crohn’s disease using real‑world prospective data, so its findings are directly relevant to treatment choice, expectations for 1‑year remission,...
Upadacitinib is already used for some patients with UC and Crohn's; this article offers a structured way to think about why it can act quickly in refractory cases and what evidence would be needed to move from short‑term...
Epigenetic control of intestinal epithelial cells can shape gut microbes and influence colitis severity; understanding SETD2’s role could point to new mechanistic targets for IBD research and microbiome-directed...
Researchers found that immune cells detect the gut-associated yeast Debaryomyces hansenii via Dectin-1 and Card9, and the yeast was enriched in Crohn’s disease ulcers. That suggests a possible microbial–immune link...
If epithelial cells themselves retain disease-linked programs, that could help explain persistent intestinal abnormalities in Crohn’s disease even during remission and point to new biomarker or therapeutic targets...
Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Genetics and genomics. The original article is from msn.com.
Fatigue is a frequent, impactful symptom in Crohn’s disease that often goes unmeasured in clinic visits. Knowing which assessment tools exist can help patients and clinicians recognize and address fatigue.
The work helps bridge genetic association signals and the specific immune cells in the intestine where they may act, offering new candidate genes and a method that can probe rare cell types important to IBD biology.
ILC3s live in the intestine and help regulate barrier function and inflammation, so mapping how genetic variants affect gene regulation in these rare cells helps connect inherited risk signals to plausible biology for...
This profile shows how someone with Crohn’s disease can continue competitive athletic pursuits while managing the condition. It highlights common issues for people with IBD—remission, stress-related flares,...
Mapping 3D genome contacts in rare gut immune cells connects Crohn’s disease genetic risk variants to specific genes and pathways, which can clarify disease mechanisms and guide future drug-target research. The study...
ILC3s are rare but important for gut immunity; linking Crohn’s disease genetic risk to the genes they regulate helps move from statistical association toward biological mechanisms that could explain disease pathways.
This study helps move beyond assigning GWAS risk variants to the nearest gene by mapping 3D promoter contacts in gut-enriched ILC3s, so it uncovers new candidate genes and pathways that could explain Crohn’s and other...
The study helps explain how noncoding genetic variants may influence Crohn’s disease by altering 3D genome interactions in rare gut-associated immune cells (ILC3s), pointing to new genes and pathways that could be...
Researchers are exploring new antioxidant nanozymes that can be given orally to reduce intestinal inflammation in lab models. If these approaches eventually translate to humans, they could become an additional strategy...
UGI involvement in children with IBD was common and linked to a more severe disease course — lower remission rates and more frequent need for biologic therapy — which could affect monitoring and treatment planning.
This research links a specific gut-associated yeast to activation of innate immune pathways (Dectin-1–Card9) that drive inflammatory signaling. For people with Crohn disease, it suggests fungal members of the gut...
Cure8 found this source from Inflammatory bowel diseases, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Pregnancy and fertility. Open the original article for the full...
Dietary patterns are being studied as therapies for pediatric IBD because they may help induce remission or improve disease control without drugs.
Diet-based therapies like CDED + PEN may help control Crohn’s symptoms and improve nutrition without adding medications. This study suggests some adults can maintain remission and gain nutritional benefits over a year...
This review examines a noninvasive neuromodulation strategy (ta‑VNS) that might modulate immune and gut‑barrier biomarkers in IBD and could become an adjunctive therapy if validated in trials. Patients and clinicians may...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Biomarkers. The original article is from Biochemistry and Biophysics Reports.
