Ulcerative colitis

Sleep timing and morning light are modifiable, nonpharmacologic factors that could influence IBD quality of life and symptoms. If effective, a simple at-home light therapy could be an accessible adjunct to usual care.

This registry entry describes a completed Phase 2 study of a new IV drug (tulisokibart) for moderate–severe ulcerative colitis, including safety endpoints and a companion diagnostic — information patients may want when...

This observational study aims to link nutritional status and the dietary inflammatory potential to IBD activity and to test whether simple blood-derived inflammatory indices can serve as noninvasive markers of disease...

This study looks at how immunomodulators are actually used with biologic drugs in real-world practice when a national reimbursement policy forces biologic interruptions.

If you or someone you care for is not responding to anti‑TNF drugs for ulcerative colitis, this review explains biological reasons why that may happen and points toward research directions that could lead to better tests...

Researchers are investigating circRNAs as potential biomarkers and therapeutic targets in IBD because they may help explain disease mechanisms and lead to better diagnostics or treatments in the future.

Depressive symptoms during remission were associated with worse long-term physical, mental, and disease-specific quality of life, so attending to mental health can matter for overall wellbeing in IBD.

The study outlines a strategy to target corticosteroids to inflamed intestinal tissue by exploiting PLA2 overexpression, which could reduce systemic steroid side effects if the approach translates to biological models...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Diet and lifestyle. The original article is from Food and Chemical Toxicology.

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Pharmacological...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Sensors and Actuators...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Phytomedicine.

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Fitoterapia.

People with ulcerative colitis may be interested because the study identifies a botanical extract (Cortex Phellodendri alkaloids) that reduced disease in a mouse model and restored intestinal barrier markers, suggesting...

People with UC may care because the study identifies a compound and a signaling pathway that lowered inflammation and tissue injury in a commonly used mouse model of colitis, suggesting potential future therapeutic...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis and Tests and monitoring. The original article is from Academic Radiology.

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...

This study points to a plant-derived compound (Astragalus polysaccharides) that reduced colitis severity in a rat model by interfering with HMGB1/TLR4-driven neutrophil extracellular trap formation—pathways implicated in...

Digital health tools could offer more continuous monitoring and self-management support for people with IBD, potentially helping detect flares earlier and improve quality of life. This review collects existing evidence...

The study identifies distinct fecal bile acid signatures in CRC versus UC that might help develop noninvasive tests to distinguish malignancy from chronic inflammatory disease of the colon.

SLE can affect the gut and sometimes looks like ulcerative colitis, so patients with atypical IBD features or new systemic signs may need immunological testing to avoid misdiagnosis.

The study suggests a common environmental pollutant could worsen intestinal inflammation in experimental colitis and identifies molecular pathways that might mediate that effect, which could be relevant to understanding...

Based on the title and source metadata, this appears to be a clinical trial phase 2 related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from...

The findings suggest blood DNA methylation changes may mark UC long before symptoms start; that could eventually enable earlier risk identification or research into preventing progression to symptomatic disease.

People with IBD who don’t respond well to ustekinumab may need alternative options. This study will track how patients fare after switching to guselkumab in routine clinical care and report rates of deep remission at one...

The study explores breath VOCs as a possible noninvasive biomarker for IBD activity, which could offer easier, more acceptable monitoring than colonoscopy or stool tests.

Researchers are exploring plant-derived polyphenols as potential anti-inflammatory agents for IBD. This preclinical study suggests a Tsaoko Fructus extract reduced colitis in mice, altered the gut microbiome toward...

The letter highlights salidroside as a potential multi-target agent that could modulate neuro-immune interactions and protect the gut barrier — mechanisms relevant to ulcerative colitis. Patients and clinicians may see...

Preclinical work identified a plant-root extract fraction that reduced inflammation and improved some gut-barrier and microbiome features in a mouse model of ulcerative colitis, which could guide future research into new...

Improving oral delivery and colon targeting of probiotics could make probiotic therapies more effective for ulcerative colitis by increasing survival through the gut and retention at inflamed sites. If translated to...

The study reports a newly discovered class of marine-derived meroterpenoids and identifies a lead compound that reduced inflammatory markers and improved colitis in mice, which could eventually inform new drug...

For people with UC on long-term tofacitinib, this trial provides evidence about the chances of keeping remission after stepping down dose and about safety differences between 10 mg and 5 mg twice daily over 30 months.

Patients with UC who appear healed on endoscopy can still relapse; a biopsy-based model could help separate lower- and higher-risk patients and guide monitoring or research enrollment.

Arthritis is a common and meaningful extraintestinal problem for people with IBD; understanding diagnosis and treatment options can help patients and clinicians seek appropriate multidisciplinary care.

The study identifies a new compound that reduced colitis severity in mice by acting on macrophage NF-κB signaling, lowering MMP7, improving epithelial barrier markers, and altering the gut microbiome — mechanisms...

This large, population-level analysis summarizes long-term global trends in IBD burden and shows rising incidence and persistent geographic and socio-demographic inequalities. Patients and clinicians may see why...

The work searches for shared blood-based gene signatures and biomarkers across HLA-B27–linked diseases (including Crohn’s disease and ulcerative colitis), which could point to common mechanisms or cross-disease...

The study suggests a plant-derived extract can reduce inflammation and help restore the intestinal epithelial barrier in laboratory models of ulcerative colitis, which is directly relevant to research into new IBD...

The study suggests that polyphenols can change gut bacteria and metabolite production differently in people with IBD versus healthy controls, which could matter for designing personalized dietary interventions.

This paper identifies a herbal formula that improved inflammation and epithelial barrier repair in a mouse colitis model and highlights specific molecular pathways (CAV1/FAK/paxillin and metabolite pathways) that might...

Clostridium difficile infection is an important and potentially serious complication in ulcerative colitis. A blood‑marker–based risk model could help identify higher‑risk patients noninvasively so clinicians can...

Different protein sources may affect IBD risk and relapses, especially for ulcerative colitis, and diet choices could be relevant to patients and clinicians managing IBD.

Researchers identified molecular features of a proposed “ferro‑aging” state in UC and nominated CHST15 and MSN as biomarkers, which could help understand disease biology and point to new experimental targets for therapy...

A systematic review finds risankizumab (an IL-23 inhibitor) effective and generally well tolerated for moderate-to-severe Crohn's disease and ulcerative colitis, including in patients who failed prior biologics. This...

Distinguishing UC from Crohn’s colitis can be challenging but affects long-term management and surveillance. A histologic feature—homogeneity versus heterogeneity of epithelial lesions across biopsies—might help improve...