Ulcerative colitis

Researchers identified a plant-derived molecule (oxypalmatine) that reduced inflammation in a mouse colitis model by blocking pro-inflammatory macrophage activity through the RAB8A–STAT1 pathway. This suggests a...

A plant polysaccharide (PVP) reduced inflammation and preserved intestinal barrier proteins in a mouse model of ulcerative colitis, apparently by increasing a specific gut bacterium. This points to a microbiome-related...

A new IL-17A drug (vunakizumab) is reported to have triggered severe ulcerative colitis in one patient, suggesting clinicians and patients starting IL-17A inhibitors should watch for early gastrointestinal symptoms.

Researchers are working to link specific gut microbes and their metabolites to host molecular changes in ulcerative colitis. This study maps candidate microbe–metabolite–host gene connections that could point to new...

Switching biologics is a frequent and consequential decision in children with IBD; using TDM and a mechanism‑based approach can help choose whether to optimize, switch within class, or change drug class.

Mental health conditions (depression, anxiety, ADHD) appear to increase before and after IBD diagnosis, suggesting psychological care may be needed earlier in the diagnostic pathway and long term.

Patients with UC and their clinicians may encounter CMV on colon biopsy testing; this study suggests CMV detection is linked with higher mucosal inflammation and a less favorable long-term course, highlighting a...

Physical activity may be a modifiable factor that could improve fitness, inflammation, symptoms like fatigue, and quality of life in children with IBD. This trial will provide objective, randomized data relevant to...

Awareness events connect people with Crohn’s and ulcerative colitis to local resources, support networks, and advocacy efforts. They can raise visibility and reduce isolation for people living with IBD.

Finding reliable blood biomarkers for ulcerative colitis activity could make monitoring disease flares easier and less dependent on invasive tests. NGAL and S100A12 rising with active disease suggests they might help...

Researchers identified licochalcone B as a compound that reduced inflammation and repaired gut barrier in a mouse colitis model by affecting PI3K/AKT signaling and purine metabolism. For people following IBD research,...

This is the official FDA drug label for dexamethasone sodium phosphate. It names ulcerative colitis and regional enteritis (Crohn’s disease) among indications where systemic corticosteroids can be used, so it’s relevant...

This FDA drug-label update describes approved uses and safety warnings for tofacitinib, a JAK inhibitor used in immune-mediated diseases including ulcerative colitis. The boxed warnings highlight serious infection and...

Sarcopenia (loss of muscle mass/strength) was common among hospitalized adults with active UC and linked to inflammation, changes in blood metabolites (bile acids, acylcarnitines), and shifts in the gut microbiome.

The work highlights macrophage metabolic programs and specific genes that may help classify UC molecular subtypes and suggest candidate biomarkers or therapeutic targets related to macrophage-driven inflammation.

PSC — a serious bile-duct disease linked to IBD — was found on MRCP in about 1 in 10 people at IBD diagnosis, often without abnormal liver blood tests. Early radiological detection could affect monitoring and specialist...

This is the official FDA label text for dexamethasone, so it clarifies approved uses and gives practical dosing and tapering guidance. It explicitly names "regional enteritis and ulcerative colitis," which matters to...

This label update confirms current FDA prescribing information for sulfasalazine delayed‑release tablets, which many people with ulcerative colitis may be prescribed for induction and maintenance of remission.

Label updates list safety warnings and monitoring steps that can affect people taking APRISO (mesalamine) for ulcerative colitis. Knowing these helps patients and clinicians watch for serious side effects and manage...

This FDA label page documents official prescribing information for SOLU-CORTEF (hydrocortisone), including explicit gastrointestinal/IBD indications (regional enteritis and ulcerative colitis) and IV/IM dosing guidance.

Medication adherence affects how well IBD maintenance treatment works. This study highlights the everyday challenges and beliefs that shape whether people stick with prescribed therapies, which can help clinicians and...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Diet and lifestyle. The original article is from Journal of Functional Foods.

Many people with IBD change their diets and avoid foods they believe trigger flares. Differences between Crohn’s disease and ulcerative colitis were observed, and many—especially those with UC—reported not receiving...

Vitamin D deficiency is common in people with IBD and this study suggests correcting deficiency may help rebalance immune cells and the microbiome—potentially supporting inflammation control alongside standard...

People with COPD can have coexisting type‑2 inflammatory conditions, and those conditions become more common with higher blood eosinophil counts. Knowing this may influence clinicians’ attention to extra‑pulmonary T2...

Preclinical results suggest a fermented yak milk–derived probiotic strain may protect against colitis in mice by improving barrier function, lowering inflammatory cytokines, and changing the gut microbiome—mechanisms...

Patients and clinicians often seek adjunctive options to improve symptoms, quality of life, or reduce treatment burden. This trial tests whether Bacillus spore probiotics added to standard care can provide measurable...

Mapping microbes and metabolites directly from different gut regions could reveal location-specific changes linked to IBD activity and help researchers develop better biomarkers or targeted treatments.

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and AI and data science. The original article is from International journal of surgery...

The study suggests that air pollutant NO2 may promote a perforin-producing CD8+ T cell response linked to colonic inflammation in UC and highlights CDC25B as a potential mechanistic link—information that could guide...

The study suggests that in some people with IBD who have Candida overgrowth, systemic antifungal therapy (fluconazole) can change gut microbes and metabolites in ways linked to better disease activity over 8 weeks. That...

This study reports that combining an anti-TNF-α drug with vedolizumab helped many children with IBD who failed single-biologic therapy achieve clinical, endoscopic, and histologic improvement. It also notes serious...

The review highlights metabolic pathways (mTOR–glycolysis) that drive inflammation and barrier dysfunction in ulcerative colitis, which could point to new kinds of targeted therapies beyond current immunosuppressive...

This gives families and clinicians a non‑TNF biologic option on‑label for children aged 2+ with moderate‑to‑severe ulcerative colitis, which can change insurance conversations and expand treatment choices for kids who...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Drug...

Ileal pouch disorders are common after IPAA surgery and cause symptoms many patients will experience. Early recognition and initial treatment by primary care can speed symptom relief and identify patients who need...

Proactive monitoring of adalimumab levels could help keep drug concentrations therapeutic and reduce loss of response during maintenance therapy for ulcerative colitis.

This study explores genetic risk variants (NOD2/CARD15) and local environmental factors (khat use) among young adults with IBD in Djibouti — information that may help explain regional differences in Crohn’s disease and...

The study expands the map of gut archaea and identifies archaeal species associated with IBD/UC, suggesting new microbial biomarkers and potential microbe–microbe interactions that might influence inflammation.

Label changes for RENFLEXIS affect people with Crohn's disease or ulcerative colitis who take (or may be prescribed) infliximab biosimilars — the label includes dosing, age indications, and important safety warnings that...

If you have IBD, emerging forms of regulated cell death may help explain ongoing intestinal inflammation and could become targets for future tests or treatments. This review highlights multiple RCD pathways linked to...

People with UC have lower baseline gut microbial diversity and slower recovery after PEG bowel preparation; improving recovery of beneficial microbes could matter for symptom stability and gut health. This study suggests...

The FDA approval expands an approved biologic option (ustekinumab/Stelara) to children aged two and older with moderately to severely active ulcerative colitis, giving families and clinicians another treatment choice. It...

The study suggests a steroid‑sparing combination (low‑dose atorvastatin plus reduced prednisolone) may produce stronger anti‑inflammatory and antioxidant effects than either drug alone in an animal model of ulcerative...

First-person stories show the real-life impact of Crohn’s: unpredictable flares, surgeries (including ileostomy), and long recovery can affect education, work, and mental health. Hearing recovery and remission are...

IBD patients sometimes have low iron or zinc and may try supplements. This trial tested whether two phytase-containing dietary supplements are acceptable and whether they change iron and zinc absorption in adults with...

This narrative review surveys novel biomarkers and therapeutic strategies for adult IBD, topics that could affect diagnosis, monitoring, and future treatment options for people with Crohn's disease or ulcerative colitis.

Mental health symptoms are common in people with IBD and may be influenced by both psychological and biological factors. A virtual, group psychotherapy program tailored to IBD could increase access to treatment and help...