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Ulcerative colitis

Ulcerative colitis news across medications, symptoms, monitoring, procedures, research, access, and daily life.

Page 19 of 40 · 1919 articles

Integrated microbiome and metabolomics analysis of the mechanism of inflammation-reducing effects of cyanidin-3-glucoside and blueberry pectin complexes in mice with ulcerative colitis.
International journal of biological macromolecules

Integrated microbiome and metabolomics analysis of the mechanism of inflammation-reducing effects of cyanidin-3-glucoside and blueberry pectin complexes in mice with ulcerative colitis.

This mouse study suggests a blueberry-derived anthocyanin plus pectin complex can alter gut microbes and metabolites linked to inflammation, pointing to a dietary approach that might influence ulcerative colitis biology.

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Two Levan-type fructans from Allium macrostemon Bunge alleviate dextran sulfate sodium-induced intestinal injury in Drosophila melanogaster.
International journal of biological macromolecules

Two Levan-type fructans from Allium macrostemon Bunge alleviate dextran sulfate sodium-induced intestinal injury in Drosophila melanogaster.

Researchers reported that two plant-derived fructans reduced chemically induced intestinal injury in a fruit fly model and modulated stress and regenerative signaling. For people interested in new IBD therapeutic leads,...

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Wearable perspiration sensor for continuous inflammation tracking in inflammatory bowel disease.
Inflammatory bowel diseases

Wearable perspiration sensor for continuous inflammation tracking in inflammatory bowel disease.

A wearable sensor that reliably measures inflammation markers (CRP and calprotectin) from sweat could make inflammation monitoring less invasive and more frequent for people with IBD, potentially helping detect flares...

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Pectin and Kaolin as Adjunctive Metabolic Therapy for Maintaining Remission in Ulcerative Colitis: Biological Rationale, Current Evidence and Future Clinical Perspectives
Nutrients

Pectin and Kaolin as Adjunctive Metabolic Therapy for Maintaining Remission in Ulcerative Colitis: Biological Rationale, Current Evidence and Future Clinical Perspectives

The review proposes a low-cost, non-immunosuppressive adjunctive strategy targeting the gut microbiome and luminal metabolism to help maintain remission in UC, an area of strong patient interest but limited clinical...

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Targeting the TL1A pathway in inflammatory bowel disease: mechanistic insights and emerging therapeutic pipeline.
Inflammatory bowel diseases

Targeting the TL1A pathway in inflammatory bowel disease: mechanistic insights and emerging therapeutic pipeline.

Anti‑TL1A drugs represent a new mechanism with phase 2 signals for clinical remission and endoscopic response in both UC and Crohn's disease, plus early biomarker evidence suggesting antifibrotic effects—areas directly...

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Reporting and representation of participant race, ethnicity, and sex in pediatric IBD clinical trials.
Inflammatory bowel diseases

Reporting and representation of participant race, ethnicity, and sex in pediatric IBD clinical trials.

Clinical trials shape available treatments and evidence; if groups of children (by race, ethnicity, or sex) are underrepresented, study results may not reflect how treatments work for them. This paper identifies...

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Figure 1 from: Georgiev S, Pampulova L, Abedinov P, Iliev R, Hadzhiev E, Petkov D (2026) How many risk factors are too many: massive pulmonary embolism in a patient with ulcerative colitis and steroid-induced vertebral fractures: a case report. Pharmacia 73: e208292. https://doi.org/10.3897/pharmacia.73.e208292
Pensoft Publishers

Figure 1 from: Georgiev S, Pampulova L, Abedinov P, Iliev R, Hadzhiev E, Petkov D (2026) How many risk factors are too many: massive pulmonary embolism in a patient with ulcerative colitis and steroid-induced vertebral fractures: a case report. Pharmacia 73: e208292. https://doi.org/10.3897/pharmacia.73.e208292

Cure8 could only read part of this source from Pensoft Publishers, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Complications.

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How many risk factors are too many: massive pulmonary embolism in a patient with ulcerative colitis and steroid-induced vertebral fractures: a case report
Pharmacia

How many risk factors are too many: massive pulmonary embolism in a patient with ulcerative colitis and steroid-induced vertebral fractures: a case report

People with IBD who take long-term corticosteroids may have multiple overlapping risks for venous thromboembolism (prothrombotic effects of steroids, steroid-induced osteoporosis and fractures, and immobilization).

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Figure 2 from: Georgiev S, Pampulova L, Abedinov P, Iliev R, Hadzhiev E, Petkov D (2026) How many risk factors are too many: massive pulmonary embolism in a patient with ulcerative colitis and steroid-induced vertebral fractures: a case report. Pharmacia 73: e208292. https://doi.org/10.3897/pharmacia.73.e208292
Pensoft Publishers

Figure 2 from: Georgiev S, Pampulova L, Abedinov P, Iliev R, Hadzhiev E, Petkov D (2026) How many risk factors are too many: massive pulmonary embolism in a patient with ulcerative colitis and steroid-induced vertebral fractures: a case report. Pharmacia 73: e208292. https://doi.org/10.3897/pharmacia.73.e208292

Cure8 could only read part of this source from Pensoft Publishers, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Complications.

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Microenvironment-adaptive drug delivery systems for ulcerative colitis: from pathological constraints to rational design.
Expert opinion on drug delivery

Microenvironment-adaptive drug delivery systems for ulcerative colitis: from pathological constraints to rational design.

The review connects UC pathological features to specific drug-delivery design needs, which could guide development of therapies that reach and act effectively in inflamed colon tissue. For people with UC, better-targeted...

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A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in Germany
ClinicalTrials.gov

A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in Germany

This study will gather real‑world effectiveness and patient‑reported outcome data for guselkumab in adults with moderate‑to‑severe Crohn’s disease or ulcerative colitis, which may help clinicians and patients understand...

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A Study to Observe Real-world Evidence of Guselkumab Treatment in Participants With Ulcerative Colitis and Crohn's Disease in the United Kingdom (UK)
ClinicalTrials.gov

A Study to Observe Real-world Evidence of Guselkumab Treatment in Participants With Ulcerative Colitis and Crohn's Disease in the United Kingdom (UK)

Patients and clinicians considering guselkumab for Crohn’s disease or ulcerative colitis may gain real-world evidence on how the drug performs across treatment lines and subgroups over up to 96 weeks. The study will...

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A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease
ClinicalTrials.gov

A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease

This registry will track long-term safety and clinical outcomes in children with IBD, with a focus on infliximab (an anti‑TNF biologic) versus non‑biologic therapies. Long follow-up could help identify uncommon or late...

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A Study of Guselkumab Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
ClinicalTrials.gov

A Study of Guselkumab Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

Phase 3 testing of guselkumab (an IL-23–targeting biologic) in moderately to severely active ulcerative colitis could expand treatment options if the trial meets its endpoints and shows an acceptable safety profile. The...

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The regulatory role of post-translational modifications in the pathogenesis of ulcerative colitis
Molecular Biology Reports

The regulatory role of post-translational modifications in the pathogenesis of ulcerative colitis

Understanding PTMs may help researchers identify new biomarkers or therapeutic targets for ulcerative colitis, which could eventually lead to better treatments or tests. For people with UC, this explains part of why...

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Integrated multi-omics, network pharmacology, and experimental validation reveal the protective mechanisms of curcumol against DSS-induced ulcerative colitis
Frontiers in Immunology

Integrated multi-omics, network pharmacology, and experimental validation reveal the protective mechanisms of curcumol against DSS-induced ulcerative colitis

The study identifies a plant-derived compound (curcumol) that reduced inflammation, mucosal injury, and some microbiome/metabolome disturbances in a mouse model of ulcerative colitis and links these effects to...

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Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis
World Journal of Gastroenterology

Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis

This study reports preclinical evidence that an herbal extract (EGST) reduced inflammation and epithelial cell ferroptosis in a mouse model of ulcerative colitis and in cell experiments, implicating the PPARγ/GPX4...

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A novel inflammatory bowel disease registry powered by artificial intelligence and natural language processing.
PLOS digital health

A novel inflammatory bowel disease registry powered by artificial intelligence and natural language processing.

Registries that automatically extract clinical data with AI/NLP can speed research, help identify patient cohorts for studies or trials, and may eventually support better clinical decision-making for people with IBD....

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Plasma proteomic signatures associated with ulcerative colitis risk in overweight/obesity individuals: a UK Biobank study
Scientific Reports

Plasma proteomic signatures associated with ulcerative colitis risk in overweight/obesity individuals: a UK Biobank study

If you have overweight or obesity, this study suggests measurable blood proteins linked to inflammation may be associated with higher future risk of ulcerative colitis. Identifying such markers could help research on...

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Mechanistic Insights into the Anti-Inflammatory Activity of a Sulfated α-Glucan (VpG) from Volutharpa ampullacea perryi
Macromol

Mechanistic Insights into the Anti-Inflammatory Activity of a Sulfated α-Glucan (VpG) from Volutharpa ampullacea perryi

Researchers are exploring new anti-inflammatory molecules for ulcerative colitis. Mechanistic data showing inhibition of macrophage M1 polarization, MAPK signaling, and antioxidant activity may help prioritize VpG for...

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Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment
Advanced Science

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Butyrate supports intestinal health and is often low in IBD. A single oral compound that reliably restores luminal butyrate could — if proven safe and effective in humans — offer a new way to treat ulcerative colitis or...

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Finetuning Foundation Models for Temporal Clinical Transcriptomics Data.
Bioinformatics (Oxford, England)

Finetuning Foundation Models for Temporal Clinical Transcriptomics Data.

Researchers working on IBD molecular mechanisms or biomarker discovery may find this AI-driven approach useful because it can detect temporal gene-expression patterns and suggest pathways linked to treatment response...

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Adult Intussusception and Ischemic Bowel Potentially Associated with CurQD Supplementation: A Case Report of A Diagnosis Driven by Point-of-care Ultrasound.
Clinical practice and cases in emergency medicine

Adult Intussusception and Ischemic Bowel Potentially Associated with CurQD Supplementation: A Case Report of A Diagnosis Driven by Point-of-care Ultrasound.

This single case shows that bedside ultrasound can detect serious abdominal problems (intussusception, ischemia) early in people with IBD even when initial vitals and labs look normal.

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Integrated Multi-Omics Analysis of Antarctic Krill Oil in Alleviating DSS-Induced Colitis and Modulating Gut Microbiota in Mice.
Marine drugs

Integrated Multi-Omics Analysis of Antarctic Krill Oil in Alleviating DSS-Induced Colitis and Modulating Gut Microbiota in Mice.

This preclinical study suggests Antarctic krill oil may reduce inflammation and alter the gut microbiome in a mouse model of ulcerative colitis, which could point toward microbiota-targeted nutritional strategies worth...

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Pharmacodynamic-oriented serum pharmacochemistry-based discovery of the pharmacodynamic material basis and mechanism of Ohwia caudata leaves against acute ulcerative colitis.
Journal of ethnopharmacology

Pharmacodynamic-oriented serum pharmacochemistry-based discovery of the pharmacodynamic material basis and mechanism of Ohwia caudata leaves against acute ulcerative colitis.

People with UC or IBD may be interested because the study identifies plant-derived compounds that reduce inflammation in lab models of ulcerative colitis and points to molecular pathways relevant to IBD.

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Caulerpa peltata extract protects against Dextran sodium sulfate-induced acute ulcerative colitis via modulating Nrf2 pathway
The Science of Nature

Caulerpa peltata extract protects against Dextran sodium sulfate-induced acute ulcerative colitis via modulating Nrf2 pathway

People with IBD might be interested because the study explores a new natural-product intervention that appears to reduce colitis severity in an animal model by activating the Nrf2 antioxidant pathway — a pathway already...

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Hierarchical benefit of multidimensional remission in ulcerative colitis: a systematic review and meta-analysis
BMC Gastroenterology

Hierarchical benefit of multidimensional remission in ulcerative colitis: a systematic review and meta-analysis

Achieving histologic or biochemical remission in addition to clinical and endoscopic remission was associated with substantially lower relapse risk in ulcerative colitis across multiple follow-up intervals, suggesting...

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A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants
ClinicalTrials.gov

A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants

Researchers and patients tracking new IBD therapies may care because this is the first human study of a GlaxoSmithKline investigational drug aimed at colitis/ulcerative colitis — an early step that could lead to future...

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The protein extracted from fermented Zanthoxylum bungeanum seeds mitigates DSS-induced ulcerative colitis by orchestrating inflammatory cytokine modulation, counteracting oxidative stress, and safeguarding gut microbiota homeostasis.
International journal of biological macromolecules

The protein extracted from fermented Zanthoxylum bungeanum seeds mitigates DSS-induced ulcerative colitis by orchestrating inflammatory cytokine modulation, counteracting oxidative stress, and safeguarding gut microbiota homeostasis.

The study suggests a fermented seed protein ingredient may reduce inflammation, oxidative stress, and microbiota imbalance in an experimental colitis model — mechanisms relevant to IBD. That could inform future dietary...

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Targeting Ferroptosis and Cuproptosis in Ulcerative Colitis: Findings from Comprehensive Bioinformatics and Experimental Validation
Journal of Visualized Experiments

Targeting Ferroptosis and Cuproptosis in Ulcerative Colitis: Findings from Comprehensive Bioinformatics and Experimental Validation

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Visualized...

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Electroacupuncture alleviates intestinal inflammation in rats with ulcerative colitis by regulating colonic cell autophagy and gut microbiota.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Electroacupuncture alleviates intestinal inflammation in rats with ulcerative colitis by regulating colonic cell autophagy and gut microbiota.

The study suggests electroacupuncture may reduce intestinal inflammation in a rat model of ulcerative colitis by enhancing epithelial autophagy and altering the gut microbiota—mechanisms relevant to IBD pathophysiology.

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