Evidence types
Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.
Page 12 of 15 · 709 articles
The study suggests a common food (edible bird's nest) may influence gut inflammation, barrier function, and microbiota in ways that could be relevant to IBD research and future dietary interventions.
This study identifies a plant-derived compound (poricoic acid A) that reduced inflammation, cellular senescence, and colon injury in cell and mouse models of ulcerative colitis and links those effects to AMPK/PPARγ...
Intestinal fibrosis is a serious complication of long-standing ulcerative colitis. Identifying NET-related biomarkers (IL1RN, MUC1, SERPINA1) could help researchers develop better diagnostic tools or treatments targeting...
The study nominates specific compounds and molecular targets from a traditional herbal formulation that could be investigated as potential anti-inflammatory agents for ulcerative colitis, helping bridge chemical...
The paper reports a material that preserved barrier proteins and reduced inflammatory signaling in cell and mouse models of ulcerative colitis; this could point to a low-cost adjunct approach for protecting the colonic...
This research links a bacterial surface capsule to how well a gut microbe colonizes the intestine and to lower inflammatory responses in mouse models, which may help explain strain differences seen in Crohn’s disease and...
The work links fungal strain variation to differences in adhesion and immune recognition, which could help explain why a normally food-associated yeast is found in Crohn disease ulcers and point to microbial features...
If validated, transient modulation of epithelial E‑cadherin could become a new approach to promote mucosal healing — a key goal in IBD care. The findings point to epithelial repair biology rather than an approved patient...
The report shows a guideline-grounded AI tool for IBD professionals can be deployed internationally and attract repeated use, suggesting potential for AI to help synthesize guideline information.
The study identifies a compound (DDIE) that reduced cellular senescence and improved colitis in a mouse model by modulating AKT and GSK3B, suggesting a new avenue for drug development in ulcerative colitis focused on...
The study describes a novel hydrogel designed to deliver sinapic acid directly to the inflamed colon and release drug in response to a reducing environment—an approach that could improve targeted oral therapies for...
The study links paternal exposure to an emerging PFAS chemical (OBS) with epigenetic changes in sperm that may increase offspring susceptibility to colitis, highlighting a possible environmental pathway relevant to IBD...
Cure8 found this source from Nature genetics, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article for the full details.
The study identifies a plant extract that reduced inflammation and oxidative stress and altered molecular pathways (Nrf2/Keap1, NF-κB) and lncRNA expression in a rat colitis model—potential leads for future IBD research...
The work suggests a microbe–metabolite–immune pathway (B. pseudolongum → taurine metabolites → M2 macrophages) that could point to future microbiome- or metabolite-targeted therapies for ulcerative colitis, which may be...
Identifying an RNF213-marked Treg subset may help researchers understand immune mechanisms active in UC and could lead to new biomarker or therapeutic targets in the future.
This study suggests a specific gut microbe might reduce gut inflammation in a mouse colitis model and may boost the benefit of infliximab, which could point toward microbiota‑based adjuncts to current IBD therapies.
This study proposes a specific gene (PREX1) and related cytoskeletal pathways that may help explain epithelial brush-border and microvillus damage seen in IBD. Understanding these mechanisms could eventually inform new...
The work links STAT4 — a gene locus associated with IBD — to Th17 pathogenic behavior and suppression of the anti-inflammatory cytokine IL-10, offering a possible mechanism by which STAT4 variants could worsen gut...
If local complement Factor B helps the gut heal, it could change how researchers think about targeting complement in IBD — suggesting local regulation rather than systemic inhibition. That’s important because complement...
Spatial, high-plex mapping of immune cells in the colon helps reveal how immune cells and stromal cells are organized in IBD versus normal tissue. That information could help researchers identify new biomarkers or...
The abstract suggests a new AhR-targeting drug candidate, EQ504, may more strongly drive epithelial repair and barrier-related gene changes in lab models than an existing clinical AhR agonist, which could be relevant to...
The study identifies TRPM5 in CD4 T cells as a modulator of T cell activation and intestinal inflammation in a mouse colitis model, which could help researchers exploring new immune-pathway targets for IBD.
This study suggests that boosting Nrf2 activity in CD4+ T cells can reduce inflammatory Th1/Th17 responses and increase regulatory T cells, which may help control colonic inflammation in ulcerative colitis.
The study identifies a new molecular mechanism (CTSH citrullination) that appears to drive NETs formation and worsen colitis in mice, which could point toward future therapies targeting PAD4–CTSH–NETs pathways. That...
This research suggests a common environmental contaminant (6PPD-quinone from tire rubber) can disrupt lipid metabolism and mitochondrial function in human colon cells and increase inflammatory signals linked to IBD.
The study points to a new local mechanism—ferroportin in colon macrophages—that links iron handling, the microbiome, and mucosal healing. If validated, this could lead to targeted treatments that help healing without...
The paper identifies Siglec‑E as an immune brake that limits colitis severity and colitis‑associated tumor development in mice, connecting an immune‑regulatory pathway to inflammation‑driven colorectal cancer risk—an...
The paper identifies a biologic pathway that links epithelial AhR signaling to NK cell–mediated tumor surveillance in the colon. For people with IBD, mechanisms that increase immune escape could relate to...
A humanized DSS colitis model that recreates human T cell and myeloid responses could make preclinical testing of human-specific biologics (like anti-TNF antibodies) more relevant to people with IBD.
The study suggests C. difficile colonization may expand IL1B+ monocytes that recruit neutrophils and amplify inflammation in ulcerative colitis, a pathway that could help explain pathogen-associated flares.
If successful, orally available small-molecule α4β7 inhibitors could offer a non-injectable alternative to current antibody therapy (vedolizumab) that targets the same gut-homing integrin—potentially widening treatment...
The work suggests soluble factors present in fecal filtrates from active UC patients can provoke proinflammatory responses in a controlled intestine-on-chip model, supporting the idea that microbiome-derived metabolites...
The study identifies a probiotic species (B. pseudolongum) and its acetate production as potential ways to limit a genotoxic E. coli and reduce inflammation in a mouse model — suggesting a microbiome-based avenue that...
The work links a missing bacterial metabolite (HDCA) to macrophage metabolism and reduced intestinal inflammation in experimental models, highlighting a potential microbiome-derived pathway that could be targeted for...
This study identifies plant extracts—especially Commiphora gileadensis—that reduced inflammation and tissue injury in cell assays and an acute rat model of ulcerative colitis, suggesting new leads for future IBD drug...
The study identifies a natural compound that reduced inflammation and improved multiple aspects of intestinal barrier function in a zebrafish IBD model, suggesting a new candidate for preclinical drug discovery relevant...
The study suggests that combining different fermentable fibers may steer the gut microbiome toward more butyrate-producing bacteria and away from pro-inflammatory lineages—changes that could be relevant to IBD-related...
The study links TRAIL expression to macrophage behavior and colitis severity in mice and to higher TRAIL levels in human IBD tissue, suggesting TRAIL-related pathways could influence intestinal inflammation and might be...
The study identifies a candidate compound (NCTD) that reduced inflammation and tissue damage in a rat ulcerative colitis model and implicates specific inflammatory, epigenetic, metabolic, and antioxidant pathways —...
The study identifies specific anti-inflammatory compounds in Artemisia scoparia and shows they reduce inflammation in cell and mouse models of ulcerative colitis, suggesting potential new leads for drug or...
The paper highlights how the gut microbiome and environment can strongly influence colitis severity in genetically susceptible mice, illustrating a gene–environment–microbiome axis that may help explain heterogeneity in...
The study identifies a potential new mechanism—blocking ferroptosis via CA9—for reducing intestinal inflammation in a mouse model, which could guide future IBD drug research.
This preclinical study identifies benzoylpaeoniflorin (BPF) as a compound that improved experimental colitis in mice by changing macrophage polarization via the RNF31–DPEP2–NF-κB pathway. It highlights a possible...
The study identifies a fungal β-glucan that reduced inflammation and altered the gut microbiome and short-chain fatty acids in a mouse model of ulcerative colitis, which could inform future nutritional or therapeutic...
Altered NAD metabolism may influence inflammation and tissue repair in IBD; understanding host and microbial contributions could open new research directions for metabolic biomarkers or therapeutic targets.
This mouse study identifies a novel peptide that reduced DSS-induced colitis and points to mast cells and fibroblast–mast cell interactions as potential therapeutic targets. It also showed additive benefit when combined...
The study explores a novel method to reduce gut oxidative stress — a contributor to IBD inflammation — by using an engineered probiotic to edit NOX2, which could point toward new therapeutic strategies if translated to...
